Ortho-toluene sulphonamide and saccharin in the promotion of bladder cancer in the rat

The importance of the contaminant OTS in the promoting activity of commercial saccharin on rat bladder neoplasia was investigated. OTS, OTS-free and OTS-contaminated saccharin were administered in the drinking water or diet for 2 years to groups of rats pretreated with an intravesical instillation o...

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Bibliographic Details
Published in:British journal of cancer 1980-07, Vol.42 (1), p.129-147
Main Authors: Hooson, J, Hicks, R M, Grasso, P, Chowaniec, J
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Body Weight - drug effects
Cancer Research
Drinking - drug effects
Drug Resistance
Eating - drug effects
Epidemiology
Female
Kidney - pathology
Methylnitrosourea
Molecular Medicine
Neoplasms, Experimental - chemically induced
Neoplasms, Experimental - pathology
Oncology
Organ Size - drug effects
original-article
Rats
Saccharin - adverse effects
Sulfonamides
Toluene - analogs & derivatives
Tosyl Compounds - adverse effects
Urinary Bladder - pathology
Urinary Bladder Neoplasms - chemically induced
Urinary Bladder Neoplasms - pathology
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Summary:The importance of the contaminant OTS in the promoting activity of commercial saccharin on rat bladder neoplasia was investigated. OTS, OTS-free and OTS-contaminated saccharin were administered in the drinking water or diet for 2 years to groups of rats pretreated with an intravesical instillation of MNU, OTS alone and OTS-free saccharin were also given to groups of rats not pretreated with MNU. Administration of OTS was not associated with changes in urinary pH, crystalluria or calculus formation, had no effect on the histology of normal rat bladder, and did not increase the incidence of bladder hyperplasia or neoplasia elicited by pretreatment with MNU. No differences could be found between the effect of OTS-free or OTS-contaminated saccharin on bladders of rats pretreated with MNU. These results indicate that OTS contamination played no part in the reported promoting activity of saccharin on the rat bladder. Administration of saccharin did not increase urinary pH, crystalluria or calculus formation, and failed to promote bladder neoplasia after a carcinogenic dose of MNU, though the numbers of proliferative lesions in the bladder were increased.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1980.211