Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral lymphocytes from patients with solid tumours

Adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) levels of peripheral blood mononuclear cells were measured in 34 patients with various types of solid tumours. The mean ADA activity was found to be significantly lower than in controls (P less than 0.005). Patients with nonresectab...

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Bibliographic Details
Published in:British journal of cancer 1981-02, Vol.43 (2), p.196-200
Main Authors: Russo, M, Giancane, R, Apice, G, Galanti, B
Format: Article
Language:English
Subjects:
Adenosine Deaminase - blood
Adult
Biomedical and Life Sciences
Biomedicine
Cancer Research
Drug Resistance
Epidemiology
Female
Humans
Lymphocytes - enzymology
Male
Middle Aged
Molecular Medicine
Neoplasm Recurrence, Local
Neoplasms - drug therapy
Neoplasms - enzymology
Neoplasms - surgery
Nucleoside Deaminases - blood
Oncology
original-article
Pentosyltransferases - blood
Purine-Nucleoside Phosphorylase - blood
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Summary:Adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) levels of peripheral blood mononuclear cells were measured in 34 patients with various types of solid tumours. The mean ADA activity was found to be significantly lower than in controls (P less than 0.005). Patients with nonresectable tumour or with recurrence after radical surgery showed low ADA levels, while patients operated upon and without recurrence had enzymatic activity not different from that of normal controls. The mean value of PNP activity was similar to that of normal controls, no differences were observed between operated patients without recurrence and cases with nonresectable tumour or with recurrence after surgical treatment. No effects on ADA and PNP levels appeared to be induced by chemotherapy.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1981.28