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Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral lymphocytes from patients with solid tumours

Adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) levels of peripheral blood mononuclear cells were measured in 34 patients with various types of solid tumours. The mean ADA activity was found to be significantly lower than in controls (P less than 0.005). Patients with nonresectab...

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Published in:	British journal of cancer 1981-02, Vol.43 (2), p.196-200
Main Authors:	Russo, M, Giancane, R, Apice, G, Galanti, B
Format:	Article
Language:	English
Subjects:	Adenosine Deaminase - blood Adult Biomedical and Life Sciences Biomedicine Cancer Research Drug Resistance Epidemiology Female Humans Lymphocytes - enzymology Male Middle Aged Molecular Medicine Neoplasm Recurrence, Local Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - surgery Nucleoside Deaminases - blood Oncology original-article Pentosyltransferases - blood Purine-Nucleoside Phosphorylase - blood
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container_title	British journal of cancer
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creator	Russo, M Giancane, R Apice, G Galanti, B
description	Adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) levels of peripheral blood mononuclear cells were measured in 34 patients with various types of solid tumours. The mean ADA activity was found to be significantly lower than in controls (P less than 0.005). Patients with nonresectable tumour or with recurrence after radical surgery showed low ADA levels, while patients operated upon and without recurrence had enzymatic activity not different from that of normal controls. The mean value of PNP activity was similar to that of normal controls, no differences were observed between operated patients without recurrence and cases with nonresectable tumour or with recurrence after surgical treatment. No effects on ADA and PNP levels appeared to be induced by chemotherapy.
doi_str_mv	10.1038/bjc.1981.28
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The mean ADA activity was found to be significantly lower than in controls (P less than 0.005). Patients with nonresectable tumour or with recurrence after radical surgery showed low ADA levels, while patients operated upon and without recurrence had enzymatic activity not different from that of normal controls. The mean value of PNP activity was similar to that of normal controls, no differences were observed between operated patients without recurrence and cases with nonresectable tumour or with recurrence after surgical treatment. 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The mean ADA activity was found to be significantly lower than in controls (P less than 0.005). Patients with nonresectable tumour or with recurrence after radical surgery showed low ADA levels, while patients operated upon and without recurrence had enzymatic activity not different from that of normal controls. The mean value of PNP activity was similar to that of normal controls, no differences were observed between operated patients without recurrence and cases with nonresectable tumour or with recurrence after surgical treatment. No effects on ADA and PNP levels appeared to be induced by chemotherapy.</description><subject>Adenosine Deaminase - blood</subject><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphocytes - enzymology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - enzymology</subject><subject>Neoplasms - surgery</subject><subject>Nucleoside Deaminases - blood</subject><subject>Oncology</subject><subject>original-article</subject><subject>Pentosyltransferases - blood</subject><subject>Purine-Nucleoside Phosphorylase - blood</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><recordid>eNp1kUFvEzEQhS0EKqFw4ozwiQtssHfXsfdSqaoKRarUSzlbjj1uHO3ai71blAP_vRMSRXDowbLs9-nN0zxC3nO25KxRX9dbu-Sd4stavSALLpq64qqWL8mCMSYr1tXsNXlTyhafHVPyjJytpOKibhfkz6WDmEqIQB2YIURTgJro6Djn_WecbQ-oO6DjJhU8edf_ZewUHsMUoNAQ6Qg5jBvIpqf9bkDK7iZUfE4DHQ1ScSr0d5g2tKQ-ODrNQ5pzeUteedMXeHe8z8nPb9f3VzfV7d33H1eXt5VtGzlVgrXSKmjrWrRKMudXjvvOOebbTlgHbQOtMqJbeaaME2snvffcdKphEolVc04uDr7jvB7AWYyDUfWYw2DyTicT9P9KDBv9kB51zTgTvEWDT0eDnH7NUCY9hGKh702ENBcthZBcCIbg5wNocyolgz8N4Uzv29LYlt63pWuF9Id_c53YYz2ofznoBZX4AFlvcW0RV_WM3ccDHs00ZzjZIbNHkHgCcFGu1A</recordid><startdate>19810201</startdate><enddate>19810201</enddate><creator>Russo, M</creator><creator>Giancane, R</creator><creator>Apice, G</creator><creator>Galanti, B</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19810201</creationdate><title>Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral lymphocytes from patients with solid tumours</title><author>Russo, M ; Giancane, R ; Apice, G ; Galanti, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-5047c8e42254870df6d1f9dd0f495cde43e48a596f08ad5bd7fff1a9830749563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adenosine Deaminase - blood</topic><topic>Adult</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphocytes - enzymology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - enzymology</topic><topic>Neoplasms - surgery</topic><topic>Nucleoside Deaminases - blood</topic><topic>Oncology</topic><topic>original-article</topic><topic>Pentosyltransferases - blood</topic><topic>Purine-Nucleoside Phosphorylase - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Russo, M</creatorcontrib><creatorcontrib>Giancane, R</creatorcontrib><creatorcontrib>Apice, G</creatorcontrib><creatorcontrib>Galanti, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Russo, M</au><au>Giancane, R</au><au>Apice, G</au><au>Galanti, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral lymphocytes from patients with solid tumours</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>1981-02-01</date><risdate>1981</risdate><volume>43</volume><issue>2</issue><spage>196</spage><epage>200</epage><pages>196-200</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract>Adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) levels of peripheral blood mononuclear cells were measured in 34 patients with various types of solid tumours. The mean ADA activity was found to be significantly lower than in controls (P less than 0.005). Patients with nonresectable tumour or with recurrence after radical surgery showed low ADA levels, while patients operated upon and without recurrence had enzymatic activity not different from that of normal controls. The mean value of PNP activity was similar to that of normal controls, no differences were observed between operated patients without recurrence and cases with nonresectable tumour or with recurrence after surgical treatment. No effects on ADA and PNP levels appeared to be induced by chemotherapy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>6781524</pmid><doi>10.1038/bjc.1981.28</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects	Adenosine Deaminase - blood Adult Biomedical and Life Sciences Biomedicine Cancer Research Drug Resistance Epidemiology Female Humans Lymphocytes - enzymology Male Middle Aged Molecular Medicine Neoplasm Recurrence, Local Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - surgery Nucleoside Deaminases - blood Oncology original-article Pentosyltransferases - blood Purine-Nucleoside Phosphorylase - blood
title	Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral lymphocytes from patients with solid tumours
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