Possible induction of disseminated intravascular coagulation in the mouse by group B streptococcal clumping factor

A hydrochloric acid extract, the clumping factor fraction, obtained from a clumping factor-positive strain of group B streptococci, was capable of killing mice by administration after injection of heat-killed cells of group B streptococci or Escherichia coli intravenously. In mice killed between 24...

Full description

Saved in:
Bibliographic Details
Published in:British journal of experimental pathology 1986-10, Vol.67 (5), p.629-635
Main Authors: USUI, Y, ICHIMAN, Y, YOSHIDA, K, OIKAWA, K
Format: Article
Language:English
Subjects:
Animals
Bacterial Proteins - pharmacology
Bacteriology
Biological and medical sciences
Disseminated Intravascular Coagulation - etiology
Disseminated Intravascular Coagulation - pathology
Fibrin - analysis
Fundamental and applied biological sciences. Psychology
Kidney Glomerulus - pathology
Liver - pathology
Mice
Mice, Inbred Strains
Microbiology
Myocardium - pathology
Pancreas - pathology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Streptococcus agalactiae
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A hydrochloric acid extract, the clumping factor fraction, obtained from a clumping factor-positive strain of group B streptococci, was capable of killing mice by administration after injection of heat-killed cells of group B streptococci or Escherichia coli intravenously. In mice killed between 24 and 48 h later, fibrin thrombi were observed in the renal glomeruli, as well as in the heart, lung, liver, and pancreas. These findings suggest the possible induction of disseminated intravascular coagulation by these organisms in the mouse.
ISSN:0007-1021