Electron microscopic studies on the location of bacterial proliferation in the liver in murine salmonellosis

Highly susceptible inbred male C57BL/6 mice were infected with 2 X 10(7) virulent Salmonella typhimurium by intraperitoneal inoculation. Samples of the liver were removed 2 or 3 days post-infection for examination by electron microscopy. Rapid infiltration of polymorphs and macrophages was observed...

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Bibliographic Details
Published in:British journal of experimental pathology 1987-08, Vol.68 (4), p.539-550
Main Authors: FA-RONG LIN, XIU-MEI WANG, HSU, H. S, MUMAW, V. R, NAKONECZNA, I
Format: Article
Language:English
Subjects:
Animals
Bacteriology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Liver - microbiology
Liver - ultrastructure
Macrophages - microbiology
Male
Mice
Mice, Inbred C57BL
Microbiology
Microscopy, Electron
Mitosis
Neutrophils - microbiology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Phagocytosis
Salmonella Infections, Animal - microbiology
Salmonella typhimurium - ultrastructure
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Summary:Highly susceptible inbred male C57BL/6 mice were infected with 2 X 10(7) virulent Salmonella typhimurium by intraperitoneal inoculation. Samples of the liver were removed 2 or 3 days post-infection for examination by electron microscopy. Rapid infiltration of polymorphs and macrophages was observed in the site of infection. Visual evidence is presented to confirm the destruction of salmonellae within these inflammatory phagocytes as previously reported. The proliferation of the pathogens occurred in the extracellular locations of sinusoids and early lesions, and within hepatocytes.
ISSN:0007-1021