Recent developments in nitric oxide donor drugs

During the 1980s, the free radical, nitric oxide (NO), was discovered to be a crucial signalling molecule, with wide‐ranging functions in the cardiovascular, nervous and immune systems. Aside from providing a credible explanation for the actions of organic nitrates and sodium nitroprusside that have...

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Bibliographic Details
Published in:British journal of pharmacology 2007-06, Vol.151 (3), p.305-321
Main Authors: Miller, M R, Megson, I L
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiovascular Physiological Phenomena - drug effects
diazeniumdiolate
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiology
furoxan
Humans
Medical sciences
Models, Biological
Molecular Structure
nitric oxide
Nitric Oxide - physiology
nitric oxide donor drugs
Nitric Oxide Donors - chemistry
Nitric Oxide Donors - pharmacology
nitroaspirin
NONOate
organic nitrate
Pharmacology. Drug treatments
Review
S‐nitrosothiol
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Summary:During the 1980s, the free radical, nitric oxide (NO), was discovered to be a crucial signalling molecule, with wide‐ranging functions in the cardiovascular, nervous and immune systems. Aside from providing a credible explanation for the actions of organic nitrates and sodium nitroprusside that have long been used in the treatment of angina and hypertensive crises respectively, the discovery generated great hopes for new NO‐based treatments for a wide variety of ailments. Decades later, however, we are still awaiting novel licensed agents in this arena, despite an enormous research effort to this end. This review explores some of the most promising recent advances in NO donor drug development and addresses the challenges associated with NO as a therapeutic agent. British Journal of Pharmacology (2007) 151, 305–321; doi:10.1038/sj.bjp.0707224
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0707224