Angioedema due to ACE inhibitors: increased risk in patients of African origin

• Published in: British journal of clinical pharmacology 1999-12, Vol.48 (6), p.861-865
• Main Authors: GIBBS, C. R, LIP, G. Y. H, BEEVERS, D. G
• Format: Article
• Language: English
• Subjects: ACE inhibitors; Adult; African Continental Ancestry Group; Aged; Aged, 80 and over; angioedema; Angioedema - chemically induced; Angioedema - ethnology; Angiotensin-Converting Enzyme Inhibitors - adverse effects; Biological and medical sciences; Drug toxicity and drugs side effects treatment; ethnicity; Female; Humans; Male; Medical sciences; Middle Aged; Miscellaneous (drug allergy, mutagens, teratogens...); Original; Pharmacology. Drug treatments; Risk
• ISSN: 0306-5251; 1365-2125
• DOI: 10.1046/j.1365-2125.1999.00093.x

Aims To determine patterns in presentation, risk factors, management and outcome of patients with ACE inhibitor associated angioedema in one British teaching hospital. Methods Cases of ACE inhibitor associated angioedema in patients presenting to the City Hospital, Birmingham between 1993 and 1999 were collected and entered prospectively onto a computerised register. Results A total of 20 cases (mean age 60 years, range 42–82 years) of ACE inhibitor associated angioedema were reported (11 female and 9 male) with 65% (n=13) of patients being black/Afro‐Caribbean. In 70% of cases (n=14), angioedema occurred within 4 weeks of starting therapy, although three patients presented following long‐term treatment (24–48 months). ACE inhibitors were continued in 50% (n=10) patients, despite at least one documented episode of angioedema. Admission to hospital was necessary in 40% (n=8) patients, with three of these admitted to the intensive care unit, and one of these died as a result of severe laryngeal obstruction. Conclusions ACE inhibitor related angioedema is a serious and potentially fatal complication which is relatively rare in the general population, but is more common amongst black/Afro‐Caribbean patients. ACE inhibitors are frequently continued following an episode of angioedema and it is important that these episodes are minimised by prompt cessation of the drug, careful patient counselling and heightened awareness in all clinicians who prescribe this common group of drugs.