Herb–drug interactions: Review and assessment of report reliability

Aims  The aim of this systematic review was to assess the published clinical evidence on interactions between herbal and conventional drugs. Methods  Four electronic databases were searched for case reports, case series or clinical trials of such interactions. The data were extracted and validated u...

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Bibliographic Details
Published in:British journal of clinical pharmacology 2001-11, Vol.52 (5), p.587-595
Main Authors: Fugh‐Berman, Adriane, Ernst, E.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
alternative medicine
Biological and medical sciences
Cycadopsida
Databases as Topic
drug interaction
Drug Interactions
Drug toxicity and drugs side effects treatment
Female
Herb-Drug Interactions
herbal medicine
herbal medicines
Humans
interaction
Magnoliopsida
Male
Medical sciences
Middle Aged
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Phytotherapy - adverse effects
risk
safety
Short Reports
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Summary:Aims  The aim of this systematic review was to assess the published clinical evidence on interactions between herbal and conventional drugs. Methods  Four electronic databases were searched for case reports, case series or clinical trials of such interactions. The data were extracted and validated using a scoring system for interaction probability. Results  One hundred and eight cases of suspected interactions were found. 68.5% were classified as ‘unable to be evaluated’, 13% as ‘well‐documented’ and 18.5% as ‘possible’ interactions. Warfarin was the most common drug (18 cases) and St John's wort the most common herb (54 cases) involved. Conclusion  Herb–drug interactions undoubtedly do occur and may put individuals at risk. However our present knowledge is incomplete and more research is urgently needed.
ISSN:0306-5251
1365-2125
DOI:10.1046/j.0306-5251.2001.01469.x