Genetic pleiotropy between asthma and obesity in a community-based sample of twins

Asthma and obesity are common conditions that are strongly associated. This association might be due to shared genetic or environmental causes. We sought to determine whether a shared genetic cause is responsible for the association between asthma and obesity and to estimate the magnitude of shared...

Full description

Saved in:
Bibliographic Details
Published in:Journal of allergy and clinical immunology 2005-12, Vol.116 (6), p.1235-1241
Main Authors: Hallstrand, Teal S., Fischer, Mary E., Wurfel, Mark M., Afari, Niloofar, Buchwald, Dedra, Goldberg, Jack
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Asthma
Asthma - etiology
Asthma - genetics
Biological and medical sciences
Body Mass Index
Diseases in Twins - genetics
Ethnicity
Fundamental and applied biological sciences. Psychology
Fundamental immunology
genetic
Humans
Immunopathology
Medical sciences
Middle Aged
Models, Genetic
Obesity
Obesity - etiology
Obesity - genetics
Quantitative genetics
Risk Factors
Studies
twin
Twins
Twins, Dizygotic
Twins, Monozygotic
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Asthma and obesity are common conditions that are strongly associated. This association might be due to shared genetic or environmental causes. We sought to determine whether a shared genetic cause is responsible for the association between asthma and obesity and to estimate the magnitude of shared genetic cause. The analyses were performed with 1001 monozygotic and 383 dizygotic same-sex twin pairs within the University of Washington Twin Registry. The presence of asthma was determined by self-report of a physician diagnosis of asthma, and body mass index (BMI) was calculated by using self-reported height and weight. Obesity was defined as a BMI of 30 or greater. The association between asthma and BMI was assessed by means of mixed-effects ordinal regression. Twin correlations examined the association of asthma and obesity. Univariate and bivariate structural equation models estimated the components of variance attributable to genetic and environmental effects. A strong association between asthma and BMI was identified in the sample population ( P < .001). Substantial heritability was detected for asthma (53%) and obesity (77%), which is indicative of additive genetic influences on each disorder. The best-fitting model of shared components of variance indicated that 8% of the genetic component of obesity is shared with asthma. The covariation between obesity and asthma is predominantly caused by shared genetic risk factors for both conditions.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2005.09.016