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Safety and diagnostic accuracy of stress cardiac magnetic resonance imaging vs exercise tolerance testing early after acute ST elevation myocardial infarction

Objective:To determine the safety and diagnostic accuracy of adenosine-stress cardiac magnetic resonance (CMR) perfusion imaging early after acute ST elevation myocardial infarction (STEMI) compared with standard exercise tolerance testing (ETT).Design and setting:Cross sectional observational study...

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Published in:Heart (British Cardiac Society) 2007-11, Vol.93 (11), p.1363-1368
Main Authors: Greenwood, J P, Younger, J F, Ridgway, J P, Sivananthan, M U, Ball, S G, Plein, S
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container_title Heart (British Cardiac Society)
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creator Greenwood, J P
Younger, J F
Ridgway, J P
Sivananthan, M U
Ball, S G
Plein, S
description Objective:To determine the safety and diagnostic accuracy of adenosine-stress cardiac magnetic resonance (CMR) perfusion imaging early after acute ST elevation myocardial infarction (STEMI) compared with standard exercise tolerance testing (ETT).Design and setting:Cross sectional observational study in a university teaching hospital.Patients:35 patients admitted with first acute STEMI.Interventions:All patients underwent a CMR imaging protocol which included rest and adenosine-stress perfusion, viability, and cardiac functional assessment. All patients also had an ETT (modified Bruce protocol) and x ray coronary angiography.Main outcome measures:Safety and diagnostic accuracy of adenosine-stress perfusion CMR vs ETT early after STEMI in identifying patients with significant coronary stenosis (⩾70%) and the need for coronary revascularisation. Also, to determine if CMR can distinguish between ischaemia in the peri-infarct zone and ischaemia in remote myocardium.Results:CMR imaging was well tolerated (all patients completed the protocol) and no complications occurred. CMR was more sensitive (86% vs 48%, p = 0.0074) and more specific than ETT (100% vs 50%, p
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All patients also had an ETT (modified Bruce protocol) and x ray coronary angiography.Main outcome measures:Safety and diagnostic accuracy of adenosine-stress perfusion CMR vs ETT early after STEMI in identifying patients with significant coronary stenosis (⩾70%) and the need for coronary revascularisation. Also, to determine if CMR can distinguish between ischaemia in the peri-infarct zone and ischaemia in remote myocardium.Results:CMR imaging was well tolerated (all patients completed the protocol) and no complications occurred. CMR was more sensitive (86% vs 48%, p = 0.0074) and more specific than ETT (100% vs 50%, p&lt;0.0001) for detecting significant coronary stenosis, and more sensitive for predicting revascularisation (94% vs 56%, p = 0.039). Inducible ischaemia in the infarct related artery territory was seen in 21 of 35 patients and was associated with smaller infarct size and less transmurality of infarction.Conclusions:Adenosine-stress CMR imaging is safe early after acute STEMI and identifies patients with significant coronary stenosis more accurately than ETT.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/hrt.2006.106427</identifier><identifier>PMID: 17309909</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Accuracy ; Acute Coronary Syndromes ; Adenosine ; Aged ; Biological and medical sciences ; Cardiology. 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All patients also had an ETT (modified Bruce protocol) and x ray coronary angiography.Main outcome measures:Safety and diagnostic accuracy of adenosine-stress perfusion CMR vs ETT early after STEMI in identifying patients with significant coronary stenosis (⩾70%) and the need for coronary revascularisation. Also, to determine if CMR can distinguish between ischaemia in the peri-infarct zone and ischaemia in remote myocardium.Results:CMR imaging was well tolerated (all patients completed the protocol) and no complications occurred. CMR was more sensitive (86% vs 48%, p = 0.0074) and more specific than ETT (100% vs 50%, p&lt;0.0001) for detecting significant coronary stenosis, and more sensitive for predicting revascularisation (94% vs 56%, p = 0.039). Inducible ischaemia in the infarct related artery territory was seen in 21 of 35 patients and was associated with smaller infarct size and less transmurality of infarction.Conclusions:Adenosine-stress CMR imaging is safe early after acute STEMI and identifies patients with significant coronary stenosis more accurately than ETT.</description><subject>Accuracy</subject><subject>Acute Coronary Syndromes</subject><subject>Adenosine</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Clinical medicine</subject><subject>Coronary Angiography</subject><subject>Coronary heart disease</subject><subject>Coronary Stenosis - diagnosis</subject><subject>Coronary Stenosis - therapy</subject><subject>Coronary vessels</subject><subject>Cross-Sectional Studies</subject><subject>Electrocardiography</subject><subject>Exercise Test - methods</subject><subject>Exercise Tolerance</subject><subject>Female</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - adverse effects</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>myocardial infarction</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - therapy</subject><subject>myocardial ischaemia</subject><subject>myocardial perfusion</subject><subject>Myocardial Revascularization</subject><subject>Myocarditis. 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Vascular system</topic><topic>Cardiovascular disease</topic><topic>Clinical medicine</topic><topic>Coronary Angiography</topic><topic>Coronary heart disease</topic><topic>Coronary Stenosis - diagnosis</topic><topic>Coronary Stenosis - therapy</topic><topic>Coronary vessels</topic><topic>Cross-Sectional Studies</topic><topic>Electrocardiography</topic><topic>Exercise Test - methods</topic><topic>Exercise Tolerance</topic><topic>Female</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - adverse effects</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>myocardial infarction</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - therapy</topic><topic>myocardial ischaemia</topic><topic>myocardial perfusion</topic><topic>Myocardial Revascularization</topic><topic>Myocarditis. 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All patients also had an ETT (modified Bruce protocol) and x ray coronary angiography.Main outcome measures:Safety and diagnostic accuracy of adenosine-stress perfusion CMR vs ETT early after STEMI in identifying patients with significant coronary stenosis (⩾70%) and the need for coronary revascularisation. Also, to determine if CMR can distinguish between ischaemia in the peri-infarct zone and ischaemia in remote myocardium.Results:CMR imaging was well tolerated (all patients completed the protocol) and no complications occurred. CMR was more sensitive (86% vs 48%, p = 0.0074) and more specific than ETT (100% vs 50%, p&lt;0.0001) for detecting significant coronary stenosis, and more sensitive for predicting revascularisation (94% vs 56%, p = 0.039). Inducible ischaemia in the infarct related artery territory was seen in 21 of 35 patients and was associated with smaller infarct size and less transmurality of infarction.Conclusions:Adenosine-stress CMR imaging is safe early after acute STEMI and identifies patients with significant coronary stenosis more accurately than ETT.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>17309909</pmid><doi>10.1136/hrt.2006.106427</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Accuracy
Acute Coronary Syndromes
Adenosine
Aged
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular disease
Clinical medicine
Coronary Angiography
Coronary heart disease
Coronary Stenosis - diagnosis
Coronary Stenosis - therapy
Coronary vessels
Cross-Sectional Studies
Electrocardiography
Exercise Test - methods
Exercise Tolerance
Female
Heart
Heart attacks
Humans
magnetic resonance imaging
Magnetic Resonance Imaging - adverse effects
Magnetic Resonance Imaging - methods
Male
Medical imaging
Medical sciences
Middle Aged
myocardial infarction
Myocardial Infarction - diagnosis
Myocardial Infarction - physiopathology
Myocardial Infarction - therapy
myocardial ischaemia
myocardial perfusion
Myocardial Revascularization
Myocarditis. Cardiomyopathies
Patient Selection
Patients
Studies
title Safety and diagnostic accuracy of stress cardiac magnetic resonance imaging vs exercise tolerance testing early after acute ST elevation myocardial infarction
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