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Safety and diagnostic accuracy of stress cardiac magnetic resonance imaging vs exercise tolerance testing early after acute ST elevation myocardial infarction
Objective:To determine the safety and diagnostic accuracy of adenosine-stress cardiac magnetic resonance (CMR) perfusion imaging early after acute ST elevation myocardial infarction (STEMI) compared with standard exercise tolerance testing (ETT).Design and setting:Cross sectional observational study...
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Published in: | Heart (British Cardiac Society) 2007-11, Vol.93 (11), p.1363-1368 |
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description | Objective:To determine the safety and diagnostic accuracy of adenosine-stress cardiac magnetic resonance (CMR) perfusion imaging early after acute ST elevation myocardial infarction (STEMI) compared with standard exercise tolerance testing (ETT).Design and setting:Cross sectional observational study in a university teaching hospital.Patients:35 patients admitted with first acute STEMI.Interventions:All patients underwent a CMR imaging protocol which included rest and adenosine-stress perfusion, viability, and cardiac functional assessment. All patients also had an ETT (modified Bruce protocol) and x ray coronary angiography.Main outcome measures:Safety and diagnostic accuracy of adenosine-stress perfusion CMR vs ETT early after STEMI in identifying patients with significant coronary stenosis (⩾70%) and the need for coronary revascularisation. Also, to determine if CMR can distinguish between ischaemia in the peri-infarct zone and ischaemia in remote myocardium.Results:CMR imaging was well tolerated (all patients completed the protocol) and no complications occurred. CMR was more sensitive (86% vs 48%, p = 0.0074) and more specific than ETT (100% vs 50%, p |
doi_str_mv | 10.1136/hrt.2006.106427 |
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All patients also had an ETT (modified Bruce protocol) and x ray coronary angiography.Main outcome measures:Safety and diagnostic accuracy of adenosine-stress perfusion CMR vs ETT early after STEMI in identifying patients with significant coronary stenosis (⩾70%) and the need for coronary revascularisation. Also, to determine if CMR can distinguish between ischaemia in the peri-infarct zone and ischaemia in remote myocardium.Results:CMR imaging was well tolerated (all patients completed the protocol) and no complications occurred. CMR was more sensitive (86% vs 48%, p = 0.0074) and more specific than ETT (100% vs 50%, p<0.0001) for detecting significant coronary stenosis, and more sensitive for predicting revascularisation (94% vs 56%, p = 0.039). Inducible ischaemia in the infarct related artery territory was seen in 21 of 35 patients and was associated with smaller infarct size and less transmurality of infarction.Conclusions:Adenosine-stress CMR imaging is safe early after acute STEMI and identifies patients with significant coronary stenosis more accurately than ETT.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/hrt.2006.106427</identifier><identifier>PMID: 17309909</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Accuracy ; Acute Coronary Syndromes ; Adenosine ; Aged ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular disease ; Clinical medicine ; Coronary Angiography ; Coronary heart disease ; Coronary Stenosis - diagnosis ; Coronary Stenosis - therapy ; Coronary vessels ; Cross-Sectional Studies ; Electrocardiography ; Exercise Test - methods ; Exercise Tolerance ; Female ; Heart ; Heart attacks ; Humans ; magnetic resonance imaging ; Magnetic Resonance Imaging - adverse effects ; Magnetic Resonance Imaging - methods ; Male ; Medical imaging ; Medical sciences ; Middle Aged ; myocardial infarction ; Myocardial Infarction - diagnosis ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; myocardial ischaemia ; myocardial perfusion ; Myocardial Revascularization ; Myocarditis. Cardiomyopathies ; Patient Selection ; Patients ; Studies</subject><ispartof>Heart (British Cardiac Society), 2007-11, Vol.93 (11), p.1363-1368</ispartof><rights>2007 BMJ Publishing Group and British Cardiac Society</rights><rights>2007 INIST-CNRS</rights><rights>Copyright: 2007 2007 BMJ Publishing Group and British Cardiac Society</rights><rights>Copyright © 2007 BMJ Publishing Group and British Cardiovascular Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b553t-23e04b754b45254948ee1305c52cdf87473a91d62f0aa18bf28d7b429c70f9363</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2016919/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2016919/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19149094$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17309909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greenwood, J P</creatorcontrib><creatorcontrib>Younger, J F</creatorcontrib><creatorcontrib>Ridgway, J P</creatorcontrib><creatorcontrib>Sivananthan, M U</creatorcontrib><creatorcontrib>Ball, S G</creatorcontrib><creatorcontrib>Plein, S</creatorcontrib><title>Safety and diagnostic accuracy of stress cardiac magnetic resonance imaging vs exercise tolerance testing early after acute ST elevation myocardial infarction</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><description>Objective:To determine the safety and diagnostic accuracy of adenosine-stress cardiac magnetic resonance (CMR) perfusion imaging early after acute ST elevation myocardial infarction (STEMI) compared with standard exercise tolerance testing (ETT).Design and setting:Cross sectional observational study in a university teaching hospital.Patients:35 patients admitted with first acute STEMI.Interventions:All patients underwent a CMR imaging protocol which included rest and adenosine-stress perfusion, viability, and cardiac functional assessment. All patients also had an ETT (modified Bruce protocol) and x ray coronary angiography.Main outcome measures:Safety and diagnostic accuracy of adenosine-stress perfusion CMR vs ETT early after STEMI in identifying patients with significant coronary stenosis (⩾70%) and the need for coronary revascularisation. Also, to determine if CMR can distinguish between ischaemia in the peri-infarct zone and ischaemia in remote myocardium.Results:CMR imaging was well tolerated (all patients completed the protocol) and no complications occurred. CMR was more sensitive (86% vs 48%, p = 0.0074) and more specific than ETT (100% vs 50%, p<0.0001) for detecting significant coronary stenosis, and more sensitive for predicting revascularisation (94% vs 56%, p = 0.039). Inducible ischaemia in the infarct related artery territory was seen in 21 of 35 patients and was associated with smaller infarct size and less transmurality of infarction.Conclusions:Adenosine-stress CMR imaging is safe early after acute STEMI and identifies patients with significant coronary stenosis more accurately than ETT.</description><subject>Accuracy</subject><subject>Acute Coronary Syndromes</subject><subject>Adenosine</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Clinical medicine</subject><subject>Coronary Angiography</subject><subject>Coronary heart disease</subject><subject>Coronary Stenosis - diagnosis</subject><subject>Coronary Stenosis - therapy</subject><subject>Coronary vessels</subject><subject>Cross-Sectional Studies</subject><subject>Electrocardiography</subject><subject>Exercise Test - methods</subject><subject>Exercise Tolerance</subject><subject>Female</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - adverse effects</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>myocardial infarction</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - therapy</subject><subject>myocardial ischaemia</subject><subject>myocardial perfusion</subject><subject>Myocardial Revascularization</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Patient Selection</subject><subject>Patients</subject><subject>Studies</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkstu1DAUhiMEoqWwZocsIVggZeprHG-Q0Ihry0VqQd1ZjnMydcnExXZGnZfhWXGaUQtsurJ1zuf_XPwXxVOCF4Sw6vA8pAXFuFoQXHEq7xX7hFd1STE5u5_vTIiywkzuFY9ivMAYc1VXD4s9IhlWCqv94veJ6SBtkRla1DqzGnxMziJj7RiM3SLfoZgCxIisCRmwaJ0hmJgc9YMZLCCXY25YoU1EcAXBuggo-R7CdTZBlsxZMKHPhboEIeuPCdDJKYIeNiY5P6D11s8leuSGzgQ7RR8XDzrTR3iyOw-K7-_eni4_lMdf339cvjkuGyFYKikDzBspeMMFFVzxGoAwLKygtu1qySUzirQV7bAxpG46Wrey4VRZiTvFKnZQvJ51L8dmDa2FIQXT68uQRwtb7Y3T_2YGd65XfqPzpitFVBZ4uRMI_teYJ9ZrFy30vRnAj1FXNatFLnQnSDHDktY8g8__Ay_8GIa8BU1kjStF5XXdw5mywccYoLvpmWA9WURni-jJInq2SH7x7O9Rb_mdJzLwYgeYaE3fTb_o4i2nCM_Y1GA5cy4muLrJm_BTV5JJob_8WOpP8ujsiH_7rEXmX818s764s8s_FUrkPA</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Greenwood, J P</creator><creator>Younger, J F</creator><creator>Ridgway, J P</creator><creator>Sivananthan, M U</creator><creator>Ball, S G</creator><creator>Plein, S</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><general>BMJ Group</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7TS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20071101</creationdate><title>Safety and diagnostic accuracy of stress cardiac magnetic resonance imaging vs exercise tolerance testing early after acute ST elevation myocardial infarction</title><author>Greenwood, J P ; Younger, J F ; Ridgway, J P ; Sivananthan, M U ; Ball, S G ; Plein, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b553t-23e04b754b45254948ee1305c52cdf87473a91d62f0aa18bf28d7b429c70f9363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Accuracy</topic><topic>Acute Coronary Syndromes</topic><topic>Adenosine</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Clinical medicine</topic><topic>Coronary Angiography</topic><topic>Coronary heart disease</topic><topic>Coronary Stenosis - diagnosis</topic><topic>Coronary Stenosis - therapy</topic><topic>Coronary vessels</topic><topic>Cross-Sectional Studies</topic><topic>Electrocardiography</topic><topic>Exercise Test - methods</topic><topic>Exercise Tolerance</topic><topic>Female</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - adverse effects</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>myocardial infarction</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - therapy</topic><topic>myocardial ischaemia</topic><topic>myocardial perfusion</topic><topic>Myocardial Revascularization</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Patient Selection</topic><topic>Patients</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greenwood, J P</creatorcontrib><creatorcontrib>Younger, J F</creatorcontrib><creatorcontrib>Ridgway, J P</creatorcontrib><creatorcontrib>Sivananthan, M U</creatorcontrib><creatorcontrib>Ball, S G</creatorcontrib><creatorcontrib>Plein, S</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greenwood, J P</au><au>Younger, J F</au><au>Ridgway, J P</au><au>Sivananthan, M U</au><au>Ball, S G</au><au>Plein, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety and diagnostic accuracy of stress cardiac magnetic resonance imaging vs exercise tolerance testing early after acute ST elevation myocardial infarction</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>93</volume><issue>11</issue><spage>1363</spage><epage>1368</epage><pages>1363-1368</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>Objective:To determine the safety and diagnostic accuracy of adenosine-stress cardiac magnetic resonance (CMR) perfusion imaging early after acute ST elevation myocardial infarction (STEMI) compared with standard exercise tolerance testing (ETT).Design and setting:Cross sectional observational study in a university teaching hospital.Patients:35 patients admitted with first acute STEMI.Interventions:All patients underwent a CMR imaging protocol which included rest and adenosine-stress perfusion, viability, and cardiac functional assessment. All patients also had an ETT (modified Bruce protocol) and x ray coronary angiography.Main outcome measures:Safety and diagnostic accuracy of adenosine-stress perfusion CMR vs ETT early after STEMI in identifying patients with significant coronary stenosis (⩾70%) and the need for coronary revascularisation. Also, to determine if CMR can distinguish between ischaemia in the peri-infarct zone and ischaemia in remote myocardium.Results:CMR imaging was well tolerated (all patients completed the protocol) and no complications occurred. CMR was more sensitive (86% vs 48%, p = 0.0074) and more specific than ETT (100% vs 50%, p<0.0001) for detecting significant coronary stenosis, and more sensitive for predicting revascularisation (94% vs 56%, p = 0.039). Inducible ischaemia in the infarct related artery territory was seen in 21 of 35 patients and was associated with smaller infarct size and less transmurality of infarction.Conclusions:Adenosine-stress CMR imaging is safe early after acute STEMI and identifies patients with significant coronary stenosis more accurately than ETT.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>17309909</pmid><doi>10.1136/hrt.2006.106427</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Accuracy Acute Coronary Syndromes Adenosine Aged Biological and medical sciences Cardiology. Vascular system Cardiovascular disease Clinical medicine Coronary Angiography Coronary heart disease Coronary Stenosis - diagnosis Coronary Stenosis - therapy Coronary vessels Cross-Sectional Studies Electrocardiography Exercise Test - methods Exercise Tolerance Female Heart Heart attacks Humans magnetic resonance imaging Magnetic Resonance Imaging - adverse effects Magnetic Resonance Imaging - methods Male Medical imaging Medical sciences Middle Aged myocardial infarction Myocardial Infarction - diagnosis Myocardial Infarction - physiopathology Myocardial Infarction - therapy myocardial ischaemia myocardial perfusion Myocardial Revascularization Myocarditis. Cardiomyopathies Patient Selection Patients Studies |
title | Safety and diagnostic accuracy of stress cardiac magnetic resonance imaging vs exercise tolerance testing early after acute ST elevation myocardial infarction |
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