Association between Arsenic Exposure from Drinking Water and Plasma Levels of Soluble Cell Adhesion Molecules

• Published in: Environmental health perspectives 2007-10, Vol.115 (10), p.1415-1420
• Main Authors: Chen, Yu, Santella, Regina M., Muhammad G. Kibriya, Wang, Qiao, Maya Kappil, Wendy J. Verret, Graziano, Joseph H., Ahsan, Habibul
• Format: Article
• Language: English
• Subjects: Adult; Arsenic; Arsenic - blood; Arsenic - urine; Arsenic Poisoning - epidemiology; Arsenic Poisoning - immunology; Bangladesh - epidemiology; Biological markers; Biomarkers - blood; Cardiovascular diseases; Cardiovascular Diseases - physiopathology; Cell adhesion molecules; Composition; Drinking water; Environmental Exposure; Environmental health; Epidemiologic Studies; Epidemiology; Evaluation; Female; Health aspects; Humans; Inflammation; Intercellular Adhesion Molecule-1 - blood; Lesions; Male; Melanosis; Middle Aged; Potable water; Prospective Studies; Risk factors; Selenium; Type 2 diabetes mellitus; Vascular Cell Adhesion Molecule-1 - blood; Vitamin E; Water Pollutants, Chemical - adverse effects; Water Supply
• ISSN: 0091-6765; 1552-9924
• DOI: 10.1289/ehp.10277

Background: Epidemiologic studies of cardiovascular disease risk factors and appropriate biomarkers in populations exposed to a wide range of arsenic levels are a public health research priority. Objective: We investigated the relationship between inorganic arsenic exposure from drinking water and plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1), both markers of endothelial dysfunction and vascular inflammation, in an arsenic-exposed population in Araihazar, Bangladesh. Methods: The study participants included 115 individuals with arsenic-related skin lesions participating in a 2 x 2 randomized, placebo-controlled, double-blind trial of vitamin E and selenium supplementation. Arsenic exposure status and plasma levels of sICAM-1 and sVCAM-1 were assessed at baseline and after 6 months of follow-up. Results: Baseline well arsenic, a long-term measure of arsenic exposure, was positively associated with baseline levels of both sICAM-1 and sVCAM-1 and with changes in the two markers over time. At baseline, for every 1-µg/L increase in well arsenic there was an increase of 0.10 ng/mL [95% confidence interval (CI), 0.00-0.20] and 0.33 ng/mL (95% CI, 0.15-0.51) in plasma sICAM-1 and sVCAM-1, respectively. Every 1-µg/L increase in well arsenic was associated with a rise of 0.11 ng/mL (95% CI, 0.01-0.22) and 0.17 ng/mL (95% CI, 0.00-0.35) in sICAM-1 and sVCAM-1 from baseline to follow-up, respectively, in spite of recent changes in urinary arsenic as well as vitamin E and selenium supplementation during the study period. Conclusions: The findings indicate an effect of chronic arsenic exposure from drinking water on vascular inflammation that persists over time and also suggest a potential mechanism underlying the association between arsenic exposure and cardiovascular disease.