Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

Part I of this report appeared in the previous issue (Br. J. Cancer (1976) 34,585), and discussed the design of randomized clinical trials. Part II now describes efficient methods of analysis of randomized clinical trials in which we wish to compare the duration of survival (or the time until some o...

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Bibliographic Details
Published in:British journal of cancer 1977-01, Vol.35 (1), p.1-39
Main Authors: Peto, R, Pike, M C, Armitage, P, Breslow, N E, Cox, D R, Howard, S V, Mantel, N, McPherson, K, Peto, J, Smith, P G
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cancer Research
Drug Evaluation
Drug Resistance
Epidemiology
Humans
Leukemia - therapy
Methods
Molecular Medicine
Mortality
Multiple Myeloma - drug therapy
Oncology
original-article
Prognosis
Remission, Spontaneous
Research Design
Statistics as Topic
Time Factors
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Description
Summary:Part I of this report appeared in the previous issue (Br. J. Cancer (1976) 34,585), and discussed the design of randomized clinical trials. Part II now describes efficient methods of analysis of randomized clinical trials in which we wish to compare the duration of survival (or the time until some other untoward event first occurs) among different groups of patients. It is intended to enable physicians without statistical training either to analyse such data themselves using life tables, the logrank test and retrospective stratification, or, when such analyses are presented, to appreciate them more critically, but the discussion may also be of interest to statisticians who have not yet specialized in clinical trial analyses.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1977.1