A new cell line from a human chondrosarcoma

Morphological and growth characteristics are described of a rapidly growing cell line with epithelioid and giant-cell characteristics derived from a chondrosarcoma in a male patient 65 years of age. This cell line is of considerable interest because in these cells cross-reacting antigens with known...

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Bibliographic Details
Published in:British journal of cancer 1977-04, Vol.35 (4), p.403-414
Main Authors: de Man, J C, Snoep, M P, Huiskens-van der Meij, J W, Warnaar, S O, Schaberg, A
Format: Article
Language:English
Subjects:
Aged
Biomedical and Life Sciences
Biomedicine
Bone Neoplasms - immunology
Bone Neoplasms - pathology
Cancer Research
Cell Line
Chondrosarcoma - immunology
Chondrosarcoma - pathology
Chromosomes
Drug Resistance
Epidemiology
Humans
Male
Molecular Medicine
Oncogenic Viruses - isolation & purification
Oncology
original-article
RNA Viruses - isolation & purification
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Description
Summary:Morphological and growth characteristics are described of a rapidly growing cell line with epithelioid and giant-cell characteristics derived from a chondrosarcoma in a male patient 65 years of age. This cell line is of considerable interest because in these cells cross-reacting antigens with known animal oncorna-viruses are present. Biochemically, the cells contain particles with a density of 1-16 with "cores" of density 1'23 associated with a reverse-transcriptase-like enzyme and with 70S RNA. Occasionally, virus-like particles were demonstrated by electron microscope in material derived from the culture medium.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1977.61