Role of host endocrine status in murine leukaemogenesis

Permanent changes in the endocrine status of female SJL/J and CR mice were induced by masculinization, ablation of endocrine glands, inoculation of hormones, or feeding of the chemical carcinogen DMBA. All these procedures resulted in modification of the host hormonal milieu, as shown by blood hormo...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer 1977-05, Vol.35 (5), p.621-629
Main Authors: Pierpaoli, W, Haran-Ghera, N, Kopp, H G
Format: Article
Language:English
Subjects:
9,10-Dimethyl-1,2-benzanthracene
Animals
Biomedical and Life Sciences
Biomedicine
Cancer Research
Castration
Chorionic Gonadotropin - pharmacology
Drug Resistance
Epidemiology
Female
Growth Hormone - pharmacology
Hormones - blood
Leukemia, Experimental - chemically induced
Leukemia, Experimental - etiology
Lymphoma, Non-Hodgkin - chemically induced
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Molecular Medicine
Neoplasms, Experimental - etiology
Oncology
original-article
Testosterone - analogs & derivatives
Testosterone - pharmacology
Thymectomy
Thyrotropin - pharmacology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Permanent changes in the endocrine status of female SJL/J and CR mice were induced by masculinization, ablation of endocrine glands, inoculation of hormones, or feeding of the chemical carcinogen DMBA. All these procedures resulted in modification of the host hormonal milieu, as shown by blood hormone determination. Masculinization reduced drastically the onset of lymphosarcoma and increased the incidence of systemic neoplasms respectively in DMBA-treated female SJL/J and CR mice. Continued administration of gonadotrophins increased the incidence of systemic neoplasia in CR mice. A direct correlation is suggested between onset of lymphosarcoma or other tumours in mice and a specific shift to an abnormal hormonal environment.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1977.97