Do DNA ploidy and S-phase fraction in primary tumour predict the response to chemotherapy in metastatic breast cancer?

The relationship between the response to chemotherapy with cyclophosphamide, epirubicin and fluorouracil as well as the time to progression of metastasised breast cancer and DNA ploidy and S-phase fraction (SPF) of primary tumours was examined using paraffin-embedded tumour tissue from 81 patients....

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Bibliographic Details
Published in:British journal of cancer 1995-05, Vol.71 (5), p.1029-1032
Main Authors: Hietanen, P, Blomqvist, C, Wasenius, V-M, Niskanen, E, Franssila, K, Nordling, S
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic agents
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Bone Neoplasms - secondary
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cancer Research
Chemotherapy
Cyclophosphamide - administration & dosage
DNA, Neoplasm - genetics
Drug Administration Schedule
Drug Resistance
Epidemiology
Epirubicin - administration & dosage
experimental-oncology
Female
Fluorouracil - administration & dosage
Humans
Medical sciences
Middle Aged
Molecular Medicine
Oncology
Pharmacology. Drug treatments
Ploidies
Predictive Value of Tests
S Phase - physiology
Soft Tissue Neoplasms - secondary
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Summary:The relationship between the response to chemotherapy with cyclophosphamide, epirubicin and fluorouracil as well as the time to progression of metastasised breast cancer and DNA ploidy and S-phase fraction (SPF) of primary tumours was examined using paraffin-embedded tumour tissue from 81 patients. The response to chemotherapy was significantly better in patients with tumours with a high SPF, and in addition the time to progression was longer in the high-SPF group. There was no significant difference when the DNA ploidy and response to treatment were compared.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1995.198