The effect of staphylocoagulase in the mammary gland of the mouse

Purified coagulase from a strain of S. aureus was inoculated into the mammary glands of mice which were examined at 4-hourly intervals over 28 h. Coagulase induced a neutrophil response at 4 h which was sustained throughout the experiment, and was accompanied by hyperplasia of the alveolar epitheliu...

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Bibliographic Details
Published in:British journal of experimental pathology 1982-06, Vol.63 (3), p.336-340
Main Authors: Anderson, J C, Adlam, C, Knights, J M
Format: Article
Language:English
Subjects:
Animals
Coagulase - pharmacology
Female
Hyperplasia
Mammary Glands, Animal - drug effects
Mammary Glands, Animal - pathology
Mice
Neutrophils - pathology
Serum Albumin, Bovine - pharmacology
Staphylococcus aureus
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Summary:Purified coagulase from a strain of S. aureus was inoculated into the mammary glands of mice which were examined at 4-hourly intervals over 28 h. Coagulase induced a neutrophil response at 4 h which was sustained throughout the experiment, and was accompanied by hyperplasia of the alveolar epithelium. There was no evidence of intravascular clotting. The response of the gland to coagulase was compared with the response following inoculation of 3 different strains of viable staphylococci.
ISSN:0007-1021