Effect of the inhibition of platelet function on the development of the primary atherogenic lesion in rats on a fat- and cholesterol-rich diet

• Published in: British journal of experimental pathology 1984-12, Vol.65 (6), p.701-710
• Main Authors: POTVLIEGE, P. R, MAES, L, WARSON, F, BOURGAIN, R. H
• Format: Article
• Language: English
• Subjects: Animals; Arteriosclerosis - etiology; Arteriosclerosis - pathology; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blood Platelets - drug effects; Blood Platelets - physiology; Cardiology. Vascular system; Cholesterol, Dietary - adverse effects; Dietary Fats - adverse effects; Endothelium - ultrastructure; Male; Medical sciences; Mesenteric Arteries - drug effects; Mesenteric Arteries - ultrastructure; Microscopy, Electron, Scanning; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - ultrastructure; Rats; Rats, Inbred Strains; Suloctidil - pharmacology
• ISSN: 0007-1021

The involvement of arterial smooth muscle cells in the development of atherogenic lesions following de-endothelialization and platelet-vessel wall interaction was described in detail by Ross et al. (1977). Bourgain & Six (1974) described a method for local de-endothelialization over a small area in a branch of the mesenteric artery of the male white Wistar rat. The vessel wall reaction to the endothelial cell loss was investigated in detail by Potvliege & Bourgain (1976). The reactive pattern following de-endothelialization includes both a marked hypertrophy of the smooth muscle cells, and, if induced at the site of bifurcation, is further accompanied by migration of smooth muscle cells into the subintimal layer (Potvliege & Bourgain 1980). Administration of a fat- and cholesteral-rich diet markedly increased these phenomena (Potvliege & Bourgain 1982).