Changes in whole blood and serum components of grivet monkeys with experimental respiratory Francisella tularensis infection

Grivet monkeys infected with virulent Francisella tularensis Strain Schu S4 showed significant early changes in serum levels of trace metals, triglycerides and activities of alkaline phosphatase, lactate dehydrogenase and alpha-hydroxybutyrate dehydrogenase. Free amino acid levels decreased slightly...

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Bibliographic Details
Published in:British journal of experimental pathology 1978-12, Vol.59 (6), p.630-639
Main Authors: Hambleton, P, Baskerville, A, Harris-Smith, P W, Bailey, N E
Format: Article
Language:English
Subjects:
Animals
Blood Proteins - analysis
Cercopithecus - blood
Enzymes - blood
Female
Haplorhini
Immunization
Kanamycin - therapeutic use
Male
Trace Elements - blood
Tularemia - blood
Tularemia - drug therapy
Tularemia - immunology
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Summary:Grivet monkeys infected with virulent Francisella tularensis Strain Schu S4 showed significant early changes in serum levels of trace metals, triglycerides and activities of alkaline phosphatase, lactate dehydrogenase and alpha-hydroxybutyrate dehydrogenase. Free amino acid levels decreased slightly and there was a marked increase in the phenylalanine: tyrosine ratio. Serum lysozyme activity and seromucoid levels also increased. Kanamycin therapy produced remission of overt signs but the changes in blood constituents were less readily affected. Immunization with the live vaccine strain of F. tularensis induced transient responses similar to those resulting from Schut S4 infection. Immunized monkeys subsequently challenged with the virulent Schu S4 strain showed no clinical signs or marked changes in blood constituents.
ISSN:0007-1021