Haemodynamic effects of adrenomedullin in human resistance and capacitance vessels

• Published in: British journal of clinical pharmacology 1997-07, Vol.44 (1), p.57-60
• Main Authors: Cockcroft, John R., Noon, Joseph P., Gardner‐Medwin, Janet, Bennett, Terry
• Format: Article
• Language: English
• Subjects: Adrenomedullin; Adult; arteries; Biological and medical sciences; blood flow; Brachial Artery - drug effects; Brachial Artery - physiology; Calcitonin Gene-Related Peptide - pharmacology; CGRP; Female; Forearm - blood supply; Fundamental and applied biological sciences. Psychology; Hand - blood supply; Hemodynamics. Rheology; Humans; Male; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - physiology; Original; Peptides - pharmacology; Plethysmography; Regional Blood Flow - drug effects; Vascular Capacitance - drug effects; Vascular Resistance - drug effects; Vasodilation - drug effects; Vasodilator Agents - pharmacology; veins; Veins - drug effects; Veins - physiology; Vertebrates: cardiovascular system
• ISSN: 0306-5251; 1365-2125
• DOI: 10.1046/j.1365-2125.1997.00622.x

Aims The haemodynamic effects of adrenomedullin and calcitonin gene‐related peptide (CGRP) were studied in resistance and capacitance vessels of healthy volunteers. Methods Adrenomedullin and CGRP were infused into the brachial artery of eight healthy subjects on two separate occasions at doses between 0.3–30 pmol min−1. Forearm blood flow was measured using venous occlusion plethysmography. Venodilatation to adrenomedullin and CGRP was assessed in a further eight subjects by infusing the peptides at doses between 0.3–10 pmol min−1 into a dorsal hand vein preconstricted with noradrenaline. Venodilator responses were measured as percentage reduction in noradrenaline preconstriction. Results Adrenomedullin and CGRP at a dose of 30 pmol min−1, produced an increase in forearm blood flow of 288±42% and 252±30% respectively (mean±s.e. mean, P