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Haemodynamic effects of adrenomedullin in human resistance and capacitance vessels
Aims The haemodynamic effects of adrenomedullin and calcitonin gene‐related peptide (CGRP) were studied in resistance and capacitance vessels of healthy volunteers. Methods Adrenomedullin and CGRP were infused into the brachial artery of eight healthy subjects on two separate occasions at doses betw...
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| Published in: | British journal of clinical pharmacology 1997-07, Vol.44 (1), p.57-60 |
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| container_title | British journal of clinical pharmacology |
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| creator | Cockcroft, John R. Noon, Joseph P. Gardner‐Medwin, Janet Bennett, Terry |
| description | Aims The haemodynamic effects of adrenomedullin and calcitonin gene‐related peptide (CGRP) were studied in resistance and capacitance vessels of healthy volunteers.
Methods Adrenomedullin and CGRP were infused into the brachial artery of eight healthy subjects on two separate occasions at doses between 0.3–30 pmol min−1. Forearm blood flow was measured using venous occlusion plethysmography. Venodilatation to adrenomedullin and CGRP was assessed in a further eight subjects by infusing the peptides at doses between 0.3–10 pmol min−1 into a dorsal hand vein preconstricted with noradrenaline. Venodilator responses were measured as percentage reduction in noradrenaline preconstriction.
Results Adrenomedullin and CGRP at a dose of 30 pmol min−1, produced an increase in forearm blood flow of 288±42% and 252±30% respectively (mean±s.e. mean, P |
| doi_str_mv | 10.1046/j.1365-2125.1997.00622.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2042810</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79156652</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5632-e4d7cc1238eb87c34fcdeb88dccc5609b78bf534036fd84ddf9770f433f0703d3</originalsourceid><addsrcrecordid>eNqNUV2LFDEQDKKce6c_QZgH8W3mOslkMgMi6OJ9wIEi-hyyScfLksmsyc55--_NusvivQmBdFPV1U0VIRWFhkLbXa4byjtRM8pEQ4dBNgAdY83jM7I4Ac_JAjh0tWCCviTnOa8BKKedOCNnA2spDHJBvt1oHCe7i3r0pkLn0GxzNblK24RxGtHOIfhYlXc_jzpWCbPPWx0NVjrayuiNNv7QP2DOGPIr8sLpkPH18b8gP64-f1_e1Hdfrm-XH-9qIzrOamytNIYy3uOql4a3zthS9daYQoBhJfuVE7wF3jnbt9a6QUpwLecOJHDLL8iHg-5mXpU7DcZt0kFtkh912qlJe_UUif5e_ZweFIOW9RSKwLujQJp-zZi3avTZYAg64jRnJQcquk6wQuwPRJOmnBO60xIKap-HWqu97Wpvu9rnof7moR7L6Jt_jzwNHgMo-NsjrrPRwaXipM8nGpOCAhWF9v5A--0D7v57vfq0_FoK_gc_OahK</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79156652</pqid></control><display><type>article</type><title>Haemodynamic effects of adrenomedullin in human resistance and capacitance vessels</title><source>Wiley</source><creator>Cockcroft, John R. ; Noon, Joseph P. ; Gardner‐Medwin, Janet ; Bennett, Terry</creator><creatorcontrib>Cockcroft, John R. ; Noon, Joseph P. ; Gardner‐Medwin, Janet ; Bennett, Terry</creatorcontrib><description>Aims The haemodynamic effects of adrenomedullin and calcitonin gene‐related peptide (CGRP) were studied in resistance and capacitance vessels of healthy volunteers.
Methods Adrenomedullin and CGRP were infused into the brachial artery of eight healthy subjects on two separate occasions at doses between 0.3–30 pmol min−1. Forearm blood flow was measured using venous occlusion plethysmography. Venodilatation to adrenomedullin and CGRP was assessed in a further eight subjects by infusing the peptides at doses between 0.3–10 pmol min−1 into a dorsal hand vein preconstricted with noradrenaline. Venodilator responses were measured as percentage reduction in noradrenaline preconstriction.
Results Adrenomedullin and CGRP at a dose of 30 pmol min−1, produced an increase in forearm blood flow of 288±42% and 252±30% respectively (mean±s.e. mean, P<0.001). At doses between 3 and 10 pmol min−1 adrenomedullin was significantly more potent than CGRP. The vasodilatation to both peptides was of similar duration with a biological half‐life of approximately 18 min. Adrenomedullin reversed constriction in dorsal hand veins by 84±2% (P<0.001) at a dose of 10 pmol min−1. CGRP produced a similar effect reversing constriction by 72±12% at the same dose (P<0.01). In veins, adrenomedullin was also more potent than CGRP at doses between 0.3 and 3 pmol min−1.
Conclusions The lowest dose of adrenomedullin producing significant arteriolar dilatation was calculated to produce plasma levels similar to those found in heart failure. These findings suggest that in pathophysiological conditions such as heart failure circulating levels of adrenomedullin may be within a range capable of influencing vascular resistance directly.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1046/j.1365-2125.1997.00622.x</identifier><identifier>PMID: 9241097</identifier><identifier>CODEN: BCPHBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adrenomedullin ; Adult ; arteries ; Biological and medical sciences ; blood flow ; Brachial Artery - drug effects ; Brachial Artery - physiology ; Calcitonin Gene-Related Peptide - pharmacology ; CGRP ; Female ; Forearm - blood supply ; Fundamental and applied biological sciences. Psychology ; Hand - blood supply ; Hemodynamics. Rheology ; Humans ; Male ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - physiology ; Original ; Peptides - pharmacology ; Plethysmography ; Regional Blood Flow - drug effects ; Vascular Capacitance - drug effects ; Vascular Resistance - drug effects ; Vasodilation - drug effects ; Vasodilator Agents - pharmacology ; veins ; Veins - drug effects ; Veins - physiology ; Vertebrates: cardiovascular system</subject><ispartof>British journal of clinical pharmacology, 1997-07, Vol.44 (1), p.57-60</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5632-e4d7cc1238eb87c34fcdeb88dccc5609b78bf534036fd84ddf9770f433f0703d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2751015$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9241097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cockcroft, John R.</creatorcontrib><creatorcontrib>Noon, Joseph P.</creatorcontrib><creatorcontrib>Gardner‐Medwin, Janet</creatorcontrib><creatorcontrib>Bennett, Terry</creatorcontrib><title>Haemodynamic effects of adrenomedullin in human resistance and capacitance vessels</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>Aims The haemodynamic effects of adrenomedullin and calcitonin gene‐related peptide (CGRP) were studied in resistance and capacitance vessels of healthy volunteers.
Methods Adrenomedullin and CGRP were infused into the brachial artery of eight healthy subjects on two separate occasions at doses between 0.3–30 pmol min−1. Forearm blood flow was measured using venous occlusion plethysmography. Venodilatation to adrenomedullin and CGRP was assessed in a further eight subjects by infusing the peptides at doses between 0.3–10 pmol min−1 into a dorsal hand vein preconstricted with noradrenaline. Venodilator responses were measured as percentage reduction in noradrenaline preconstriction.
Results Adrenomedullin and CGRP at a dose of 30 pmol min−1, produced an increase in forearm blood flow of 288±42% and 252±30% respectively (mean±s.e. mean, P<0.001). At doses between 3 and 10 pmol min−1 adrenomedullin was significantly more potent than CGRP. The vasodilatation to both peptides was of similar duration with a biological half‐life of approximately 18 min. Adrenomedullin reversed constriction in dorsal hand veins by 84±2% (P<0.001) at a dose of 10 pmol min−1. CGRP produced a similar effect reversing constriction by 72±12% at the same dose (P<0.01). In veins, adrenomedullin was also more potent than CGRP at doses between 0.3 and 3 pmol min−1.
Conclusions The lowest dose of adrenomedullin producing significant arteriolar dilatation was calculated to produce plasma levels similar to those found in heart failure. These findings suggest that in pathophysiological conditions such as heart failure circulating levels of adrenomedullin may be within a range capable of influencing vascular resistance directly.</description><subject>Adrenomedullin</subject><subject>Adult</subject><subject>arteries</subject><subject>Biological and medical sciences</subject><subject>blood flow</subject><subject>Brachial Artery - drug effects</subject><subject>Brachial Artery - physiology</subject><subject>Calcitonin Gene-Related Peptide - pharmacology</subject><subject>CGRP</subject><subject>Female</subject><subject>Forearm - blood supply</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hand - blood supply</subject><subject>Hemodynamics. Rheology</subject><subject>Humans</subject><subject>Male</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - physiology</subject><subject>Original</subject><subject>Peptides - pharmacology</subject><subject>Plethysmography</subject><subject>Regional Blood Flow - drug effects</subject><subject>Vascular Capacitance - drug effects</subject><subject>Vascular Resistance - drug effects</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilator Agents - pharmacology</subject><subject>veins</subject><subject>Veins - drug effects</subject><subject>Veins - physiology</subject><subject>Vertebrates: cardiovascular system</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqNUV2LFDEQDKKce6c_QZgH8W3mOslkMgMi6OJ9wIEi-hyyScfLksmsyc55--_NusvivQmBdFPV1U0VIRWFhkLbXa4byjtRM8pEQ4dBNgAdY83jM7I4Ac_JAjh0tWCCviTnOa8BKKedOCNnA2spDHJBvt1oHCe7i3r0pkLn0GxzNblK24RxGtHOIfhYlXc_jzpWCbPPWx0NVjrayuiNNv7QP2DOGPIr8sLpkPH18b8gP64-f1_e1Hdfrm-XH-9qIzrOamytNIYy3uOql4a3zthS9daYQoBhJfuVE7wF3jnbt9a6QUpwLecOJHDLL8iHg-5mXpU7DcZt0kFtkh912qlJe_UUif5e_ZweFIOW9RSKwLujQJp-zZi3avTZYAg64jRnJQcquk6wQuwPRJOmnBO60xIKap-HWqu97Wpvu9rnof7moR7L6Jt_jzwNHgMo-NsjrrPRwaXipM8nGpOCAhWF9v5A--0D7v57vfq0_FoK_gc_OahK</recordid><startdate>199707</startdate><enddate>199707</enddate><creator>Cockcroft, John R.</creator><creator>Noon, Joseph P.</creator><creator>Gardner‐Medwin, Janet</creator><creator>Bennett, Terry</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199707</creationdate><title>Haemodynamic effects of adrenomedullin in human resistance and capacitance vessels</title><author>Cockcroft, John R. ; Noon, Joseph P. ; Gardner‐Medwin, Janet ; Bennett, Terry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5632-e4d7cc1238eb87c34fcdeb88dccc5609b78bf534036fd84ddf9770f433f0703d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adrenomedullin</topic><topic>Adult</topic><topic>arteries</topic><topic>Biological and medical sciences</topic><topic>blood flow</topic><topic>Brachial Artery - drug effects</topic><topic>Brachial Artery - physiology</topic><topic>Calcitonin Gene-Related Peptide - pharmacology</topic><topic>CGRP</topic><topic>Female</topic><topic>Forearm - blood supply</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hand - blood supply</topic><topic>Hemodynamics. Rheology</topic><topic>Humans</topic><topic>Male</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - physiology</topic><topic>Original</topic><topic>Peptides - pharmacology</topic><topic>Plethysmography</topic><topic>Regional Blood Flow - drug effects</topic><topic>Vascular Capacitance - drug effects</topic><topic>Vascular Resistance - drug effects</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilator Agents - pharmacology</topic><topic>veins</topic><topic>Veins - drug effects</topic><topic>Veins - physiology</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cockcroft, John R.</creatorcontrib><creatorcontrib>Noon, Joseph P.</creatorcontrib><creatorcontrib>Gardner‐Medwin, Janet</creatorcontrib><creatorcontrib>Bennett, Terry</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cockcroft, John R.</au><au>Noon, Joseph P.</au><au>Gardner‐Medwin, Janet</au><au>Bennett, Terry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haemodynamic effects of adrenomedullin in human resistance and capacitance vessels</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1997-07</date><risdate>1997</risdate><volume>44</volume><issue>1</issue><spage>57</spage><epage>60</epage><pages>57-60</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><coden>BCPHBM</coden><abstract>Aims The haemodynamic effects of adrenomedullin and calcitonin gene‐related peptide (CGRP) were studied in resistance and capacitance vessels of healthy volunteers.
Methods Adrenomedullin and CGRP were infused into the brachial artery of eight healthy subjects on two separate occasions at doses between 0.3–30 pmol min−1. Forearm blood flow was measured using venous occlusion plethysmography. Venodilatation to adrenomedullin and CGRP was assessed in a further eight subjects by infusing the peptides at doses between 0.3–10 pmol min−1 into a dorsal hand vein preconstricted with noradrenaline. Venodilator responses were measured as percentage reduction in noradrenaline preconstriction.
Results Adrenomedullin and CGRP at a dose of 30 pmol min−1, produced an increase in forearm blood flow of 288±42% and 252±30% respectively (mean±s.e. mean, P<0.001). At doses between 3 and 10 pmol min−1 adrenomedullin was significantly more potent than CGRP. The vasodilatation to both peptides was of similar duration with a biological half‐life of approximately 18 min. Adrenomedullin reversed constriction in dorsal hand veins by 84±2% (P<0.001) at a dose of 10 pmol min−1. CGRP produced a similar effect reversing constriction by 72±12% at the same dose (P<0.01). In veins, adrenomedullin was also more potent than CGRP at doses between 0.3 and 3 pmol min−1.
Conclusions The lowest dose of adrenomedullin producing significant arteriolar dilatation was calculated to produce plasma levels similar to those found in heart failure. These findings suggest that in pathophysiological conditions such as heart failure circulating levels of adrenomedullin may be within a range capable of influencing vascular resistance directly.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>9241097</pmid><doi>10.1046/j.1365-2125.1997.00622.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenomedullin Adult arteries Biological and medical sciences blood flow Brachial Artery - drug effects Brachial Artery - physiology Calcitonin Gene-Related Peptide - pharmacology CGRP Female Forearm - blood supply Fundamental and applied biological sciences. Psychology Hand - blood supply Hemodynamics. Rheology Humans Male Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Original Peptides - pharmacology Plethysmography Regional Blood Flow - drug effects Vascular Capacitance - drug effects Vascular Resistance - drug effects Vasodilation - drug effects Vasodilator Agents - pharmacology veins Veins - drug effects Veins - physiology Vertebrates: cardiovascular system |
| title | Haemodynamic effects of adrenomedullin in human resistance and capacitance vessels |
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