SOME PROPERTIES OF 5‐HYDROXYTRYPTAMINE RECEPTORS IN THE HINDQUARTERS OF THE RAT

1 The rat hindquarter preparation, as described, responds with reproducible vasoconstriction to noradrenaline and tryptamines. 2 The receptors involved in these responses are distinct. 3 Evidence of heterogeneity of tryptamine receptors was not obtained. 4 The 5‐hydroxytryptamine (5‐HT) antagonists,...

Full description

Saved in:
Bibliographic Details
Published in:British journal of pharmacology 1979-09, Vol.67 (1), p.79-85
Main Authors: COOPER, MARIE, WYLLIE, JOHN H.
Format: Article
Language:English
Subjects:
Animals
Binding, Competitive
Blood Vessels - drug effects
Chlorpromazine - pharmacology
Hindlimb - blood supply
In Vitro Techniques
Rats
Receptors, Serotonin - drug effects
Serotonin Antagonists - pharmacology
Vasoconstriction - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1 The rat hindquarter preparation, as described, responds with reproducible vasoconstriction to noradrenaline and tryptamines. 2 The receptors involved in these responses are distinct. 3 Evidence of heterogeneity of tryptamine receptors was not obtained. 4 The 5‐hydroxytryptamine (5‐HT) antagonists, methysergide and cyproheptadine, although very potent, displayed antagonism of a non‐competitive type whereas a series of phenothiazines and phentolamine displayed competitive antagonism against 5‐HT. 5 For the phenothiazines the order of increasing potency was promazine < chlorpromazine < triflupromazine.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1979.tb16109.x