INVOLVEMENT OF SRS‐A IN THE SCHULTZ‐DALE RESPONSE OF THE GUINEA‐PIG SMALL INTESTINE

1 The anaphylactic reaction of the guinea‐pig ileum, the so called Schultz‐Dale reaction, shows a biphasic response: a short rapid contraction followed by a partial relaxation and a slow contractile response. 2 Dose‐response curves with ovalbumin as an antigen were obtained for the quick and slow co...

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Bibliographic Details
Published in:British journal of pharmacology 1979-07, Vol.66 (3), p.385-389
Main Authors: HERMAN, A.G., LAEKEMAN, G.M., BEEK, H.A.
Format: Article
Language:English
Subjects:
Anaphylaxis - chemically induced
Anaphylaxis - metabolism
Anaphylaxis - physiopathology
Animals
Female
Guinea Pigs
Histamine - pharmacology
Ileum - immunology
In Vitro Techniques
Male
Ovalbumin - immunology
SRS-A - metabolism
SRS-A - physiology
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Summary:1 The anaphylactic reaction of the guinea‐pig ileum, the so called Schultz‐Dale reaction, shows a biphasic response: a short rapid contraction followed by a partial relaxation and a slow contractile response. 2 Dose‐response curves with ovalbumin as an antigen were obtained for the quick and slow contraction of this anaphylactic reaction. 3 Mepyramine (1 μg/ml) blocked the rapid first contraction, but failed to abolish the slow one in about 50% of the animals studied. 4 The SRS‐A antagonist, FPL 55712, significantly depressed the slow sustained contraction during the Schultz‐Dale reaction. Disodiumcromoglycate was without effect on both phases when it was added 5 min before addition of the antigen. However, when added simultaneously with the antigen it produced a 30% suppression of the slow phase in the highest concentration used.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1979.tb10842.x