ENHANCEMENT OF RAT BRAIN METABOLISM OF A TRYPTOPHAN LOAD BY CHRONIC ETHANOL ADMINISTRATION

We have previously shown that chronic ethanol administration enhances brain 5‐hydroxytryptamine synthesis by increasing the availability of circulating tryptophan to the brain secondary to the decreased liver tryptophan pyrrolase activity. We now find that ethanol enhances the brain metabolism of a...

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Bibliographic Details
Published in:British journal of pharmacology 1980-01, Vol.68 (1), p.22-24
Main Authors: BADAWY, A.A.‐B., EVANS, M., PUNJANI, N.F.
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - metabolism
Brain - drug effects
Brain - metabolism
Ethanol - pharmacology
Hydroxyindoleacetic Acid - metabolism
Liver - metabolism
Rats
Serotonin - metabolism
Tryptophan - metabolism
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Summary:We have previously shown that chronic ethanol administration enhances brain 5‐hydroxytryptamine synthesis by increasing the availability of circulating tryptophan to the brain secondary to the decreased liver tryptophan pyrrolase activity. We now find that ethanol enhances the brain metabolism of a tryptophan load by the same mechanism. The results are discussed in relation to ethanol preference and the need for further clinical work on the effects of alcoholism on tryptophan metabolism.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1980.tb10694.x