Sensitivity to indomethacin of tetrodotoxin‐resistant contractions of smooth muscle from the base of rabbit bladder

Tetrodotoxin (TTX) reduced the contractions to field stimulation of strips of rabbit bladder base by 58% of control (at 40 Hz), and increased the spontaneous activity occurring between the evoked responses. The TTX‐resistant contractions resembled the spontaneous activity in that they were of compar...

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Bibliographic Details
Published in:British journal of pharmacology 1983-06, Vol.79 (2), p.334-336
Main Authors: Downie, J.W., Slack, B.E.
Format: Article
Language:English
Subjects:
Animals
In Vitro Techniques
Indomethacin - pharmacology
Male
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Prostaglandins - physiology
Rabbits
Tetrodotoxin - pharmacology
Urinary Bladder - drug effects
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Summary:Tetrodotoxin (TTX) reduced the contractions to field stimulation of strips of rabbit bladder base by 58% of control (at 40 Hz), and increased the spontaneous activity occurring between the evoked responses. The TTX‐resistant contractions resembled the spontaneous activity in that they were of comparable size and poorly sustained; in the presence of indomethacin, TTX produced a significantly greater reduction (to 13% of control at 40 Hz), of the evoked contractions. Indomethacin abolished spontaneous activity in the presence and absence of TTX, but did not affect evoked responses in strips that were not exposed to TTX. The results imply that a prostaglandin‐like substance may potentiate residual evoked responses in TTX‐treated strips, but does not contribute to field stimulation‐induced contractions in untreated bladder base smooth muscle.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1983.tb11005.x