Homogeneously staining regions in 223 breast carcinomas: cytogenetic and clinicopathological correlations

A correlation analysis was performed on 223 breast carcinomas to assess the relationships between gene amplification, karyotypic and clinicopathological features. Homogeneously staining region (HSR) is the most frequent form of amplification found in breast cancer. HSR-containing tumours accounted f...

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Bibliographic Details
Published in:British journal of cancer 1998-11, Vol.78 (9), p.1214-1218
Main Authors: Bernardino, J, Gerbault-Seureau, M, Zafrani, B, Dericke, Y, Boudou, E, Magdelenat, H, Dutrillaux, B
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cancer Research
clinical-oncology
Disease-Free Survival
Drug Resistance
Epidemiology
Female
Gene Amplification
Gynecology. Andrology. Obstetrics
Humans
Karyotyping
Lymph Nodes - pathology
Mammary gland diseases
Medical sciences
Middle Aged
Molecular Medicine
Oncology
Prognosis
Receptors, Estrogen - biosynthesis
Receptors, Progesterone - biosynthesis
Staining and Labeling - methods
Tumors
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Summary:A correlation analysis was performed on 223 breast carcinomas to assess the relationships between gene amplification, karyotypic and clinicopathological features. Homogeneously staining region (HSR) is the most frequent form of amplification found in breast cancer. HSR-containing tumours accounted for 60% of the cases. Although up to 40% of tumours with slightly altered karyotype contained HSRs, an excess of HSRs was found within the tumours whose karyotype showed the highest rates of rearranged chromosomes. HSRs were also found to be particularly frequent in small tumours of high histological grade and with a low expression of progesterone receptors. An excess of HSRs seems to be observed in younger patients, however, significant correlation could be demonstrated only for patients below 55 years and below 60 years, compared with older ones. With a 120-month follow-up for 152 patients, a significant association between the presence of HSRs and a shortened overall survival was observed. Altogether, the presence of HSRs appears to be a good indicator of poor prognosis. Further studies are needed to determine whether amplification of specific genes or cell ability to amplify is the most important parameter for tumour progression.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1998.657