NUCLEOTIDE PYROPHOSPHATASE ANTAGONIZES RESPONSES TO ADENOSINE 5′ ‐TRIPHOSPHATE AND NON‐ADRENERGIC, NON‐CHOLINERGIC INHIBITORY NERVE STIMULATION IN THE GUINEA‐PIG ISOLATED TAENIA COLI

The enzyme, nucleotide pyrophosphatase converted adenosine 5′ ‐triphosphate (ATP) to adenosine 5′ ‐monophosphate (AMP). In the isolated taenia coli of the guinea‐pig it reduced the inhibitory responses to exogenously applied ATP. This could be explained on the basis that the ATP was rapidly converte...

Full description

Saved in:
Bibliographic Details
Published in:British journal of pharmacology 1981-10, Vol.74 (2), p.319-321
Main Author: SATCHELL, D.G.
Format: Article
Language:English
Subjects:
Adenosine Monophosphate - antagonists & inhibitors
Adenosine Triphosphate - antagonists & inhibitors
Animals
Dose-Response Relationship, Drug
Electric Stimulation
Female
Guinea Pigs
In Vitro Techniques
Intestines - drug effects
Intestines - innervation
Male
Norepinephrine - pharmacology
Nucleotides - pharmacology
Pyrophosphatases - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The enzyme, nucleotide pyrophosphatase converted adenosine 5′ ‐triphosphate (ATP) to adenosine 5′ ‐monophosphate (AMP). In the isolated taenia coli of the guinea‐pig it reduced the inhibitory responses to exogenously applied ATP. This could be explained on the basis that the ATP was rapidly converted to AMP which is less potent. The enzyme also reduced inhibitory responses to stimulation of non‐adrenergic, non‐cholinergic nerves but failed to reduce inhibitory responses to either perivascular sympathetic nerve stimulation or to noradrenaline. The results support the hypothesis that ATP is the transmitter released by non‐adrenergic, non‐cholinergic (‘purinergic’) inhibitory nerves.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1981.tb09973.x