EFFECT OF DIPYRIDAMOLE ON THE FORMATION OF 6‐OXO‐PROSTAGLANDIN F1α BY THE RAT ISOLATED AORTA AND RAM SEMINAL VESICLE MICROSOMES

1 Dipyridamole (1 and 10 μm) enhanced the production of 6‐oxo‐prostaglandin F1α by rat aortic tissue. 2 Dipyridamole (5 to 40 μm) did not influence the PGI2‐synthetase activity in ram seminal vesicle microsomes whereas, in concentrations ranging from 100 to 200 μM, it reduced the metabolism of exoge...

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Bibliographic Details
Published in:British journal of pharmacology 1982-07, Vol.76 (3), p.453-458
Main Authors: BULT, HIDDE, HERMAN, ARNOLD G., VELDE, VERA J.S.
Format: Article
Language:English
Subjects:
6-Ketoprostaglandin F1 alpha - biosynthesis
Animals
Aorta - metabolism
Arachidonic Acids - metabolism
Dipyridamole - pharmacology
Epoprostenol - biosynthesis
In Vitro Techniques
Male
Microsomes - metabolism
Rats
Rats, Inbred Strains
Seminal Vesicles - metabolism
Sheep
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Summary:1 Dipyridamole (1 and 10 μm) enhanced the production of 6‐oxo‐prostaglandin F1α by rat aortic tissue. 2 Dipyridamole (5 to 40 μm) did not influence the PGI2‐synthetase activity in ram seminal vesicle microsomes whereas, in concentrations ranging from 100 to 200 μM, it reduced the metabolism of exogenously added arachidonic acid. The latter effect may be due to an inhibition of the cyclo‐oxygenase.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1982.tb09239.x