Multiplicity of fibronectin-binding αV integrin receptors in colorectal cancer

Current data from in vitro and in vivo animal models indicate that fibronectin-binding integrin receptors expressed by colon cancer cells may regulate tumour growth. While individual members of the beta 1 subfamily of integrins have now been clearly identified in colorectal cancer, little informatio...

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Bibliographic Details
Published in:British journal of cancer 1996-04, Vol.73 (7), p.887-892
Main Authors: Agrez, MV, Bates, RC, Mitchell, D, Wilson, N, Ferguson, N, Anseline, P, Sheppard, D
Format: Article
Language:English
Subjects:
Antigens, CD - metabolism
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - ultrastructure
Drug Resistance
Epidemiology
experimental-oncology
Fibronectins - metabolism
Flow Cytometry
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Integrin alphaV
Medical sciences
Molecular Medicine
Oncology
Precipitin Tests
Receptors, Fibronectin - metabolism
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumor Cells, Cultured
Tumors
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Summary:Current data from in vitro and in vivo animal models indicate that fibronectin-binding integrin receptors expressed by colon cancer cells may regulate tumour growth. While individual members of the beta 1 subfamily of integrins have now been clearly identified in colorectal cancer, little information exists with respect to the alpha V subfamily. In the present study we show that alpha V can associate with multiple and different beta subunits capable of binding fibronectin in this tumour type. This is likely to have functional implications for growth and spread of colorectal cancer.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1996.158