Mutation analysis of the c-mos proto-oncogene and the endothelin-B receptor gene in medullary thyroid carcinoma and phaeochromocytoma

The characteristic tumours of MEN 2 are medullary thyroid carcinoma (MTC) and phaeochromocytoma. Somatic RET mutations have been found in only 23-40% of sporadic MTC and 10% of sporadic phaeochromocytomas. Thus, we sought other genes which may play a role in the pathogenesis of these tumours. We car...

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Bibliographic Details
Published in:British journal of cancer 1996-08, Vol.74 (3), p.339-341
Main Authors: Eng, C, Foster, KA, Healey, CS, Houghton, C, Gayther, SA, Mulligan, LM, Ponder, BAJ
Format: Article
Language:English
Subjects:
Adrenal Gland Neoplasms - genetics
Base Sequence
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinoma, Medullary - genetics
Drosophila Proteins
Drug Resistance
Endocrinopathies
Epidemiology
experimental-oncology
General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes
Humans
Medical sciences
Molecular Medicine
Molecular Sequence Data
Multiple Endocrine Neoplasia Type 2a - genetics
Mutation
Oncology
Pheochromocytoma - genetics
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins c-ret
Proto-Oncogenes
Receptor Protein-Tyrosine Kinases - genetics
Receptor, Endothelin B
Receptors, Endothelin - genetics
Thyroid Neoplasms - genetics
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Summary:The characteristic tumours of MEN 2 are medullary thyroid carcinoma (MTC) and phaeochromocytoma. Somatic RET mutations have been found in only 23-40% of sporadic MTC and 10% of sporadic phaeochromocytomas. Thus, we sought other genes which may play a role in the pathogenesis of these tumours. We carried out direct sequence analysis of human c-mos and human ENRB in a series of sporadic MTC and phaeochromocytomas to determine if somatic mutations in these two genes could account for some of the sporadic MEN 2-related tumours in which no RET mutations are detected. No somatic mutations were found.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1996.363