5-Hydroxyindoleacetic acid (5-HIAA) and cortisol excretion as predictors of chemotherapy-induced emesis

This study evaluated the relationship between prechemotherapy cortisol and 5-hydroxyindoleacetic acid (5-HIAA) excretion and chemotherapy-induced emesis. The urinary excretion of cortisol and the serotonin metabolite 5-HIAA in the night before chemotherapy administration were measured in 28 and 49 f...

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Bibliographic Details
Published in:British journal of cancer 1996-10, Vol.74 (7), p.1137-1140
Main Authors: DU BOIS, A, VACH, W, WECHSEL, U, HOLY, R, SCHAEFER, W
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents - administration & dosage
Biological and medical sciences
Biomarkers - urine
Drug toxicity and drugs side effects treatment
Female
Humans
Hydrocortisone - urine
Hydroxyindoleacetic Acid - urine
Medical sciences
Middle Aged
Nausea - chemically induced
Nausea - urine
Pharmacology. Drug treatments
Toxicity: digestive system
Vomiting - chemically induced
Vomiting - urine
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Description
Summary:This study evaluated the relationship between prechemotherapy cortisol and 5-hydroxyindoleacetic acid (5-HIAA) excretion and chemotherapy-induced emesis. The urinary excretion of cortisol and the serotonin metabolite 5-HIAA in the night before chemotherapy administration were measured in 28 and 49 female patients receiving > 300 mg m-2 carboplatin. Vomiting and nausea were documented over a 3 day observation period. Lower basal cortisol excretion was significantly correlated with vomiting with or without nausea occurring within the observation period. 5-HIAA showed only a weak correlation with emesis on days 1-3, but low 5-HIAA excretion was correlated with a higher proportion of patients vomiting on days 2-3 following chemotherapy. Low basal cortisol excretion might be useful as a predictor for chemotherapy-induced emesis and therefore should be evaluated prospectively in future studies.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1996.503