Stress induced hypotension in pure autonomic failure

A 47 year old woman with pure autonomic failure complained of dizziness during emotional stress. Emotional stimuli have not previously been reported to cause hypotension in patients with autonomic failure. In the patient, ambulatory blood pressure recording revealed severe hypotension (50/30 mm Hg)...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2006-04, Vol.77 (4), p.552-553
Main Authors: Thijs, R D, van Dijk, J G
Format: Article
Language:English
Subjects:
autonomic failure
Autonomic Nervous System Diseases - physiopathology
Biological and medical sciences
Blood pressure
Catecholamines - blood
Catecholamines - deficiency
Drug toxicity and drugs side effects treatment
emotional stress
Female
Heart rate
Humans
Hyperventilation
hypocapnia
Hypotension, Orthostatic - diagnosis
Hypotension, Orthostatic - drug therapy
Hypotension, Orthostatic - etiology
Medical sciences
Middle Aged
Midodrine - therapeutic use
Nervous system
Neurology
Neuropharmacology
Neuroprotective agent
Orthostatic hypotension
petco2- end tidal CO2 tension
Pharmacists
Pharmacology. Drug treatments
Short Report
Stress, Psychological - psychology
Toxicity: nervous system and muscle
Treatment Outcome
Vasoconstrictor Agents - therapeutic use
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Summary:A 47 year old woman with pure autonomic failure complained of dizziness during emotional stress. Emotional stimuli have not previously been reported to cause hypotension in patients with autonomic failure. In the patient, ambulatory blood pressure recording revealed severe hypotension (50/30 mm Hg) after a stressful event. During a tilt table test, hyperventilation was shown to cause a significant fall of blood pressure. This suggests that emotional stress can induce hypotension, probably through hyperventilation, in subjects with autonomic failure.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.2005.074369