Interaction of homocysteine and conventional predisposing factors on risk of ischaemic stroke in young people: consistency in phenotype-disease analysis and genotype-disease analysis

Background and objectives: Whether the association between mild hyperhomocysteinaemia and ischaemic stroke is the consequence of a predisposing genetic background or is due to the confounding influence of established predisposing factors remains to be determined. Methods: Plasma total homocysteine (...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2006-10, Vol.77 (10), p.1150-1156
Main Authors: Pezzini, A, Grassi, M, Del Zotto, E, Assanelli, D, Archetti, S, Negrini, R, Caimi, L, Padovani, A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Atherosclerosis
Brain Ischemia - epidemiology
Brain Ischemia - genetics
Brain Ischemia - physiopathology
CART
Causality
classification and regression trees
Diabetes
Disease
Environment
Genetic Predisposition to Disease
Genotype
Homocysteine
Homocystine
Humans
Hyperhomocysteinemia - complications
Hyperhomocysteinemia - epidemiology
Hyperhomocysteinemia - genetics
Hypertension
Hypotheses
Ischemia
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
methylenetetrahydrofolate reductase gene
MTHFR
Phenotype
Plasma
Polymorphism, Genetic
Predictive Value of Tests
Registries - statistics & numerical data
Regression Analysis
Risk Factors
Smoking
Stroke
Stroke - epidemiology
Stroke - genetics
Stroke - physiopathology
tHcy
total homocysteine
Young adults
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Summary:Background and objectives: Whether the association between mild hyperhomocysteinaemia and ischaemic stroke is the consequence of a predisposing genetic background or is due to the confounding influence of established predisposing factors remains to be determined. Methods: Plasma total homocysteine (tHcy) concentration and the distribution of the C677T genotypes of the methylenetetrahydrofolate reductase gene (MTHFR) were compared in 174 consecutive patients with stroke aged
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.2005.076083