Increased perceived stress is associated with blunted hedonic capacity: Potential implications for depression research

Preclinical studies suggest that stress exerts depressogenic effects by impairing hedonic capacity; in humans, however, the precise mechanisms linking stress and depression are largely unknown. As an initial step towards better understanding the association between stress and anhedonia, the present...

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Bibliographic Details
Published in:Behaviour research and therapy 2007-11, Vol.45 (11), p.2742-2753
Main Authors: Pizzagalli, Diego A., Bogdan, Ryan, Ratner, Kyle G., Jahn, Allison L.
Format: Article
Language:English
Subjects:
Adaptation, Psychological
Adolescent
Adult
Adult and adolescent clinical studies
Affect
Anhedonia
Biological and medical sciences
Depression
Depression - etiology
Dopamine
Emotional disorders
Female
Happiness
Humans
Internal-External Control
Male
Medical research
Medical sciences
Mood disorders
Neurotransmitters
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychometrics
Psychopathology. Psychiatry
Reward
Rewards
Stress
Stress, Psychological - psychology
Studies
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Summary:Preclinical studies suggest that stress exerts depressogenic effects by impairing hedonic capacity; in humans, however, the precise mechanisms linking stress and depression are largely unknown. As an initial step towards better understanding the association between stress and anhedonia, the present study tested, in two independent samples, whether individuals reporting elevated stress exhibit decreased hedonic capacity. The Perceived Stress Scale (PSS) measured the degree to which participants appraised their daily life as unpredictable, uncontrollable, and overwhelming. Hedonic capacity was objectively assessed using a signal-detection task based on a differential reinforcement schedule. Decreased reward responsiveness (i.e., the participants’ propensity to modulate behavior as a function of reward) was used as an operational measure of hedonic capacity. In both Study 1 ( n=88) and Study 2 ( n=80), participants with high PSS scores displayed blunted reward responsiveness and reported elevated anhedonic symptoms. Additionally, PSS scores predicted reduced reward responsiveness even after controlling for general distress and anxiety symptoms. These findings are consistent with preclinical data highlighting links between stress and anhedonia, and offer promising insights into potential mechanisms linking stress to depression.
ISSN:0005-7967
1873-622X
DOI:10.1016/j.brat.2007.07.013