Dysadherin: A new player in cancer progression

Abstract Dysadherin is a cancer-associated cell membrane glycoprotein that promotes experimental cancer metastasis. Here we review recent work that has provided insights into possible mechanisms of action of this newly recognized player in the cancer progression process. Dysadherin modulates cell ph...

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Bibliographic Details
Published in:Cancer letters 2007-10, Vol.255 (2), p.161-169
Main Authors: Nam, Jeong-Seok, Hirohashi, Setsuo, Wakefield, Lalage M
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Breast cancer
Cell adhesion & migration
Chemokine (C–C motif) ligand 2
Disease Progression
Dysadherin
E-cadherin
Hematology, Oncology and Palliative Medicine
Humans
Liver cancer
Medical prognosis
Medical research
Membrane Glycoproteins - analysis
Membrane Glycoproteins - drug effects
Membrane Glycoproteins - metabolism
Metastasis
Molecular Sequence Data
Neoplasm Proteins - analysis
Neoplasm Proteins - drug effects
Neoplasm Proteins - metabolism
Neoplasms - metabolism
Neoplasms - pathology
Prognosis
Studies
Tumors
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Summary:Abstract Dysadherin is a cancer-associated cell membrane glycoprotein that promotes experimental cancer metastasis. Here we review recent work that has provided insights into possible mechanisms of action of this newly recognized player in the cancer progression process. Dysadherin modulates cell phenotype in a number of ways, including down-regulation of E-cadherin-mediated cell adhesion, and up-regulation of chemokine production. In this way, expression of dysadherin in a tumor can influence both the tumor cell itself and the stromal compartment, so as to create conditions that are more permissive for metastatic spread. Dysadherin expression is also an independent prognostic indicator of metastasis and survival for many different types of human cancer. Thus, dysadherin may represent a new molecular target for the visualization, prevention or treatment of advanced cancer.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2007.02.018