Variation in 5' Promoter Region of the APOE gene Contributes to Predicting Ischemic Heart Disease (IHD) in the Population at Large: the Copenhagen City Heart Study

Summary The objective of this study was to evaluate whether an increased hazard of developing ischemic heart disease (IHD) is associated with any of the three genotypes A560T832/A560T832, A560T832/A560G832 and A560T832/T560T832, defined by variations in two non‐coding SNPs in the 5′ promoter region...

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Bibliographic Details
Published in:Annals of human genetics 2007-11, Vol.71 (6), p.762-771
Main Authors: Stengård, J. H., Frikke‐Schmidt, R., Tybjærg‐Hansen, A., Nordestgaard, B.G., Sing, C.F.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
APOE gene
Apolipoproteins E - genetics
Cholesterol, HDL - blood
Denmark
Female
Genetic Predisposition to Disease
Genetic Testing
Genetic Variation
Genotype
Humans
Male
Middle Aged
Models, Genetic
Myocardial Ischemia - blood
Myocardial Ischemia - etiology
Myocardial Ischemia - genetics
Polymorphism, Single Nucleotide
prediction of IHD
Promoter Regions, Genetic
Prospective Studies
regulatory variation
Risk Factors
Sex Factors
Triglycerides - blood
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Summary:Summary The objective of this study was to evaluate whether an increased hazard of developing ischemic heart disease (IHD) is associated with any of the three genotypes A560T832/A560T832, A560T832/A560G832 and A560T832/T560T832, defined by variations in two non‐coding SNPs in the 5′ promoter region of the apolipoprotein E (APOE) gene. These genotypes were selected because they distinguished between high and low levels of HDL‐C, TG and/or T‐C in our earlier study of multiple samples defined by gender and population. We found a significant increase (p
ISSN:0003-4800
1469-1809
DOI:10.1111/j.1469-1809.2007.00370.x