Gene–environment interactions

Conclusion: The -238A TNF-[alpha] polymorphism is associated with persistent bone marrow dysplasia in workers exposed to relatively high concentrations of benzene. Since TNF-[alpha] is involved in haematopoietic stem cell regulation as well as inflammation and altered immune response, these findings...

Full description

Saved in:
Bibliographic Details
Published in:Occupational and environmental medicine (London, England) England), 2007-12, Vol.64 (12), p.e14-e14
Main Authors: Battie, M. C., Videman, T., Levalahti, E., Kaprio, J., Bisceglia, L., de Nichilo, G., Carrus, A., Corsi, P., Vimercati, L., Assennato, G., Fustinoni, S., Campo, L., Ashley-Martin, J., Guernsey, J., Cribb, A., Van Leeuwen, J., Andreou, P., Schnatter, A. R., Irons, R. D., Ling, L., Kerzic, P., Bao, L., Yang, Y., Zou, H., Fu, H., Ye, X., Gross, S., Armstrong, T., Burstyn, I., Kim, H. M., Cherry, N. M., Li, S., Yasui, Y.
Format: Article
Language:English
Subjects:
Back pain
Benzene
Biomarkers
Bone marrow
Breast cancer
Deoxyribonucleic acid
DNA
Electronic Pages
Epidemiology
Estimates
Genes
Genotype-environment interactions
Health risk assessment
Hydrocarbons
Immune response
Influence
Logistics
Mammography
Metabolism
Objectives
Occupational exposure
Pesticides
Quantitative genetics
Stem cells
Studies
Tumor necrosis factor-TNF
Workers
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Conclusion: The -238A TNF-[alpha] polymorphism is associated with persistent bone marrow dysplasia in workers exposed to relatively high concentrations of benzene. Since TNF-[alpha] is involved in haematopoietic stem cell regulation as well as inflammation and altered immune response, these findings suggest a potential role for these modes of action in benzene-induced dysplasia and possibly leukemogenesis. Key words: tumour necrosis factor; benzene; bone marrow dysplasia 067 IMPACT OF MEASUREMENT ERRORS IN CUMULATIVE EXPOSURE ON THE EVALUATION OF GENE-ENVIRONMENT INTERACTION IN A CASE-CONTROL STUDY:
ISSN:1351-0711
1470-7926
DOI:10.1136/oem.64.12.e14