Non-operative breast pathology: apocrine lesions

Apocrine metaplasia is a very common finding in the female breast after the age of 25. It is so common that many people regard it as a normal component of the breast. This, however, is only really the case in apocrine sweat glands of the axilla and in the peri-areolar apocrine glands. The apocrine c...

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Bibliographic Details
Published in:Journal of clinical pathology 2007-12, Vol.60 (12), p.1313-1320
Main Authors: Wells, C A, El-Ayat, G A
Format: Article
Language:English
Subjects:
Adenoma - pathology
adenosis
apocrine
apocrine carcinoma
Apocrine Glands - metabolism
Apocrine Glands - pathology
atypical
Biopsy
breast
Breast - pathology
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Breasts
Carcinoma, Ductal, Breast - pathology
Cysts
Cytoplasm
Epidermal growth factor
Female
Fibrocystic Breast Disease - pathology
Gene expression
Humans
Hyperplasia - pathology
metaplasia
Metaplasia - pathology
Neoplasm Invasiveness
Pathology
Potassium
Precancerous Conditions - metabolism
Precancerous Conditions - pathology
Proteins
Studies
Tumors
Womens health
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Summary:Apocrine metaplasia is a very common finding in the female breast after the age of 25. It is so common that many people regard it as a normal component of the breast. This, however, is only really the case in apocrine sweat glands of the axilla and in the peri-areolar apocrine glands. The apocrine cell does, however, contribute to a number of different breast lesions, some of which are very taxing diagnostically; apocrine variants of both in-situ and invasive cancer are encountered. This review considers the common apocrine metaplastic lesions seen in fibrocystic change as well as apocrine adenoma, apocrine change within sclerosing adenosis, atypical apocrine lesions and apocrine malignancies.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.2006.040626