Faecal S100A12 as a non-invasive marker distinguishing inflammatory bowel disease from irritable bowel syndrome

Objective:S100A12 is a pro-inflammatory protein that is secreted by granulocytes. S100A12 serum levels increase during inflammatory bowel disease (IBD). We performed the first study analysing faecal S100A12 in adults with signs of intestinal inflammation.Methods:Faecal S100A12 was determined by ELIS...

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Published in:Gut 2007-12, Vol.56 (12), p.1706-1713
Main Authors: Kaiser, T, Langhorst, J, Wittkowski, H, Becker, K, Friedrich, A W, Rueffer, A, Dobos, G J, Roth, J, Foell, D
Format: Article
Language:English
Subjects:
Accuracy
Adolescent
Adult
Aged
Aged, 80 and over
Bacterial Infections - diagnosis
Biological and medical sciences
Biomarkers
Biomarkers - analysis
Biopsy
Child
Child, Preschool
Colitis, Ulcerative - diagnosis
Colleges & universities
Colon
Crohn Disease - diagnosis
Crohn's disease
Diagnosis, Differential
Endoscopy
Feces - chemistry
Female
Gastroenteritis - diagnosis
Gastroenterology. Liver. Pancreas. Abdomen
Granulocytes
Histology
Humans
Infant
Inflammation
Inflammatory Bowel Disease
Inflammatory Bowel Diseases - diagnosis
Irritable bowel syndrome
Irritable Bowel Syndrome - diagnosis
Leukocyte L1 Antigen Complex - analysis
Male
Medical sciences
Middle Aged
Neutrophils
Other diseases. Semiology
Patients
Prospective Studies
Proteins
Rodents
S100 Proteins - analysis
S100A12 Protein
Sensitivity and Specificity
Severity of Illness Index
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Virus Diseases - diagnosis
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container_end_page 1713
container_issue 12
container_start_page 1706
container_title Gut
container_volume 56
creator Kaiser, T
Langhorst, J
Wittkowski, H
Becker, K
Friedrich, A W
Rueffer, A
Dobos, G J
Roth, J
Foell, D
description Objective:S100A12 is a pro-inflammatory protein that is secreted by granulocytes. S100A12 serum levels increase during inflammatory bowel disease (IBD). We performed the first study analysing faecal S100A12 in adults with signs of intestinal inflammation.Methods:Faecal S100A12 was determined by ELISA in faecal specimens of 171 consecutive patients and 24 healthy controls. Patients either suffered from infectious gastroenteritis confirmed by stool analysis (65 bacterial, 23 viral) or underwent endoscopic and histological investigation (32 with Crohn’s disease, 27 with ulcerative colitis, and 24 with irritable bowel syndrome; IBS). Intestinal S100A12 expression was analysed in biopsies obtained from all patients. Faecal calprotectin was used as an additional non-invasive surrogate marker.Results:Faecal S100A12 was significantly higher in patients with active IBD (2.45 ± 1.15 mg/kg) compared with healthy controls (0.006 ± 0.03 mg/kg; p
doi_str_mv 10.1136/gut.2006.113431
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S100A12 serum levels increase during inflammatory bowel disease (IBD). We performed the first study analysing faecal S100A12 in adults with signs of intestinal inflammation.Methods:Faecal S100A12 was determined by ELISA in faecal specimens of 171 consecutive patients and 24 healthy controls. Patients either suffered from infectious gastroenteritis confirmed by stool analysis (65 bacterial, 23 viral) or underwent endoscopic and histological investigation (32 with Crohn’s disease, 27 with ulcerative colitis, and 24 with irritable bowel syndrome; IBS). Intestinal S100A12 expression was analysed in biopsies obtained from all patients. Faecal calprotectin was used as an additional non-invasive surrogate marker.Results:Faecal S100A12 was significantly higher in patients with active IBD (2.45 ± 1.15 mg/kg) compared with healthy controls (0.006 ± 0.03 mg/kg; p&lt;0.001) or patients with IBS (0.05 ± 0.11 mg/kg; p&lt;0.001). Faecal S100A12 distinguished active IBD from healthy controls with a sensitivity of 86% and a specificity of 100%. We also found excellent sensitivity of 86% and specificity of 96% for distinguishing IBD from IBS. Faecal S100A12 was also elevated in bacterial enteritis but not in viral gastroenteritis. Faecal S100A12 correlated better with intestinal inflammation than faecal calprotectin or other biomarkers.Conclusions:Faecal S100A12 is a novel non-invasive marker distinguishing IBD from IBS or healthy individuals with a high sensitivity and specificity. Furthermore, S100A12 reflects inflammatory activity of chronic IBD. As a marker for neutrophil activation, faecal S100A12 may significantly improve our arsenal of non-invasive biomarkers of intestinal inflammation.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>DOI: 10.1136/gut.2006.113431</identifier><identifier>PMID: 17675327</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Accuracy ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacterial Infections - diagnosis ; Biological and medical sciences ; Biomarkers ; Biomarkers - analysis ; Biopsy ; Child ; Child, Preschool ; Colitis, Ulcerative - diagnosis ; Colleges &amp; universities ; Colon ; Crohn Disease - diagnosis ; Crohn's disease ; Diagnosis, Differential ; Endoscopy ; Feces - chemistry ; Female ; Gastroenteritis - diagnosis ; Gastroenterology. Liver. Pancreas. Abdomen ; Granulocytes ; Histology ; Humans ; Infant ; Inflammation ; Inflammatory Bowel Disease ; Inflammatory Bowel Diseases - diagnosis ; Irritable bowel syndrome ; Irritable Bowel Syndrome - diagnosis ; Leukocyte L1 Antigen Complex - analysis ; Male ; Medical sciences ; Middle Aged ; Neutrophils ; Other diseases. Semiology ; Patients ; Prospective Studies ; Proteins ; Rodents ; S100 Proteins - analysis ; S100A12 Protein ; Sensitivity and Specificity ; Severity of Illness Index ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Virus Diseases - diagnosis</subject><ispartof>Gut, 2007-12, Vol.56 (12), p.1706-1713</ispartof><rights>2007 BMJ Publishing Group &amp; British Society of Gastroenterology</rights><rights>2008 INIST-CNRS</rights><rights>Copyright: 2007 2007 BMJ Publishing Group &amp; British Society of Gastroenterology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b578t-4fa4633cf90c09c18dfa8e5bf643f2c9289d0abf0aab5ae885b716940a382e9f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095695/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095695/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=19373957$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17675327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaiser, T</creatorcontrib><creatorcontrib>Langhorst, J</creatorcontrib><creatorcontrib>Wittkowski, H</creatorcontrib><creatorcontrib>Becker, K</creatorcontrib><creatorcontrib>Friedrich, A W</creatorcontrib><creatorcontrib>Rueffer, A</creatorcontrib><creatorcontrib>Dobos, G J</creatorcontrib><creatorcontrib>Roth, J</creatorcontrib><creatorcontrib>Foell, D</creatorcontrib><title>Faecal S100A12 as a non-invasive marker distinguishing inflammatory bowel disease from irritable bowel syndrome</title><title>Gut</title><addtitle>Gut</addtitle><description>Objective:S100A12 is a pro-inflammatory protein that is secreted by granulocytes. S100A12 serum levels increase during inflammatory bowel disease (IBD). We performed the first study analysing faecal S100A12 in adults with signs of intestinal inflammation.Methods:Faecal S100A12 was determined by ELISA in faecal specimens of 171 consecutive patients and 24 healthy controls. Patients either suffered from infectious gastroenteritis confirmed by stool analysis (65 bacterial, 23 viral) or underwent endoscopic and histological investigation (32 with Crohn’s disease, 27 with ulcerative colitis, and 24 with irritable bowel syndrome; IBS). Intestinal S100A12 expression was analysed in biopsies obtained from all patients. Faecal calprotectin was used as an additional non-invasive surrogate marker.Results:Faecal S100A12 was significantly higher in patients with active IBD (2.45 ± 1.15 mg/kg) compared with healthy controls (0.006 ± 0.03 mg/kg; p&lt;0.001) or patients with IBS (0.05 ± 0.11 mg/kg; p&lt;0.001). Faecal S100A12 distinguished active IBD from healthy controls with a sensitivity of 86% and a specificity of 100%. We also found excellent sensitivity of 86% and specificity of 96% for distinguishing IBD from IBS. Faecal S100A12 was also elevated in bacterial enteritis but not in viral gastroenteritis. Faecal S100A12 correlated better with intestinal inflammation than faecal calprotectin or other biomarkers.Conclusions:Faecal S100A12 is a novel non-invasive marker distinguishing IBD from IBS or healthy individuals with a high sensitivity and specificity. Furthermore, S100A12 reflects inflammatory activity of chronic IBD. As a marker for neutrophil activation, faecal S100A12 may significantly improve our arsenal of non-invasive biomarkers of intestinal inflammation.</description><subject>Accuracy</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bacterial Infections - diagnosis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Biopsy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Colitis, Ulcerative - diagnosis</subject><subject>Colleges &amp; universities</subject><subject>Colon</subject><subject>Crohn Disease - diagnosis</subject><subject>Crohn's disease</subject><subject>Diagnosis, Differential</subject><subject>Endoscopy</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Gastroenteritis - diagnosis</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Granulocytes</subject><subject>Histology</subject><subject>Humans</subject><subject>Infant</subject><subject>Inflammation</subject><subject>Inflammatory Bowel Disease</subject><subject>Inflammatory Bowel Diseases - diagnosis</subject><subject>Irritable bowel syndrome</subject><subject>Irritable Bowel Syndrome - diagnosis</subject><subject>Leukocyte L1 Antigen Complex - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neutrophils</subject><subject>Other diseases. Semiology</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Rodents</subject><subject>S100 Proteins - analysis</subject><subject>S100A12 Protein</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Granulocytes</topic><topic>Histology</topic><topic>Humans</topic><topic>Infant</topic><topic>Inflammation</topic><topic>Inflammatory Bowel Disease</topic><topic>Inflammatory Bowel Diseases - diagnosis</topic><topic>Irritable bowel syndrome</topic><topic>Irritable Bowel Syndrome - diagnosis</topic><topic>Leukocyte L1 Antigen Complex - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neutrophils</topic><topic>Other diseases. Semiology</topic><topic>Patients</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Rodents</topic><topic>S100 Proteins - analysis</topic><topic>S100A12 Protein</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Virus Diseases - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaiser, T</creatorcontrib><creatorcontrib>Langhorst, J</creatorcontrib><creatorcontrib>Wittkowski, H</creatorcontrib><creatorcontrib>Becker, K</creatorcontrib><creatorcontrib>Friedrich, A W</creatorcontrib><creatorcontrib>Rueffer, A</creatorcontrib><creatorcontrib>Dobos, G J</creatorcontrib><creatorcontrib>Roth, J</creatorcontrib><creatorcontrib>Foell, D</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaiser, T</au><au>Langhorst, J</au><au>Wittkowski, H</au><au>Becker, K</au><au>Friedrich, A W</au><au>Rueffer, A</au><au>Dobos, G J</au><au>Roth, J</au><au>Foell, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Faecal S100A12 as a non-invasive marker distinguishing inflammatory bowel disease from irritable bowel syndrome</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>56</volume><issue>12</issue><spage>1706</spage><epage>1713</epage><pages>1706-1713</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><coden>GUTTAK</coden><abstract>Objective:S100A12 is a pro-inflammatory protein that is secreted by granulocytes. S100A12 serum levels increase during inflammatory bowel disease (IBD). We performed the first study analysing faecal S100A12 in adults with signs of intestinal inflammation.Methods:Faecal S100A12 was determined by ELISA in faecal specimens of 171 consecutive patients and 24 healthy controls. Patients either suffered from infectious gastroenteritis confirmed by stool analysis (65 bacterial, 23 viral) or underwent endoscopic and histological investigation (32 with Crohn’s disease, 27 with ulcerative colitis, and 24 with irritable bowel syndrome; IBS). Intestinal S100A12 expression was analysed in biopsies obtained from all patients. Faecal calprotectin was used as an additional non-invasive surrogate marker.Results:Faecal S100A12 was significantly higher in patients with active IBD (2.45 ± 1.15 mg/kg) compared with healthy controls (0.006 ± 0.03 mg/kg; p&lt;0.001) or patients with IBS (0.05 ± 0.11 mg/kg; p&lt;0.001). Faecal S100A12 distinguished active IBD from healthy controls with a sensitivity of 86% and a specificity of 100%. We also found excellent sensitivity of 86% and specificity of 96% for distinguishing IBD from IBS. Faecal S100A12 was also elevated in bacterial enteritis but not in viral gastroenteritis. Faecal S100A12 correlated better with intestinal inflammation than faecal calprotectin or other biomarkers.Conclusions:Faecal S100A12 is a novel non-invasive marker distinguishing IBD from IBS or healthy individuals with a high sensitivity and specificity. Furthermore, S100A12 reflects inflammatory activity of chronic IBD. As a marker for neutrophil activation, faecal S100A12 may significantly improve our arsenal of non-invasive biomarkers of intestinal inflammation.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>17675327</pmid><doi>10.1136/gut.2006.113431</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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source PubMed (Medline)
subjects Accuracy
Adolescent
Adult
Aged
Aged, 80 and over
Bacterial Infections - diagnosis
Biological and medical sciences
Biomarkers
Biomarkers - analysis
Biopsy
Child
Child, Preschool
Colitis, Ulcerative - diagnosis
Colleges & universities
Colon
Crohn Disease - diagnosis
Crohn's disease
Diagnosis, Differential
Endoscopy
Feces - chemistry
Female
Gastroenteritis - diagnosis
Gastroenterology. Liver. Pancreas. Abdomen
Granulocytes
Histology
Humans
Infant
Inflammation
Inflammatory Bowel Disease
Inflammatory Bowel Diseases - diagnosis
Irritable bowel syndrome
Irritable Bowel Syndrome - diagnosis
Leukocyte L1 Antigen Complex - analysis
Male
Medical sciences
Middle Aged
Neutrophils
Other diseases. Semiology
Patients
Prospective Studies
Proteins
Rodents
S100 Proteins - analysis
S100A12 Protein
Sensitivity and Specificity
Severity of Illness Index
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Virus Diseases - diagnosis
title Faecal S100A12 as a non-invasive marker distinguishing inflammatory bowel disease from irritable bowel syndrome
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