A second-generation combined linkage physical map of the human genome

We have completed a second-generation linkage map that incorporates sequence-based positional information. This new map, the Rutgers Map v.2, includes 28,121 polymorphic markers with physical positions corroborated by recombination-based data. Sex-averaged and sex-specific linkage map distances, alo...

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Bibliographic Details
Published in:Genome Research 2007-12, Vol.17 (12), p.1783-1786
Main Authors: Matise, Tara C, Chen, Fang, Chen, Wenwei, De La Vega, Francisco M, Hansen, Mark, He, Chunsheng, Hyland, Fiona C L, Kennedy, Giulia C, Kong, Xiangyang, Murray, Sarah S, Ziegle, Janet S, Stewart, William C L, Buyske, Steven
Format: Article
Language:English
Subjects:
Confidence Intervals
Female
Genetic Linkage
Genetic Markers
Genome, Human
Genotype
Humans
Male
Physical Chromosome Mapping - methods
Physical Chromosome Mapping - statistics & numerical data
Polymorphism, Single Nucleotide
Resource
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Summary:We have completed a second-generation linkage map that incorporates sequence-based positional information. This new map, the Rutgers Map v.2, includes 28,121 polymorphic markers with physical positions corroborated by recombination-based data. Sex-averaged and sex-specific linkage map distances, along with confidence intervals, have been estimated for all map intervals. In addition, a regression-based smoothed map is provided that facilitates interpolation of positions of unmapped markers on this map. With nearly twice as many markers as our first-generation map, the Rutgers Map continues to be a unique and comprehensive resource for obtaining genetic map information for large sets of polymorphic markers.
ISSN:1088-9051
1549-5469
1549-5477
DOI:10.1101/gr.7156307