Neutrophilic inflammation and IL-8 levels in induced sputum of alpha-1-antitrypsin PiMZ subjects

Background: Severe alpha-1-antitrypsin deficiency (AATD), due to homozygosity for the protease inhibitor (Pi) Z allele, is a genetic risk factor for chronic obstructive pulmonary disease (COPD). In a previous study the sputum of severe AATD subjects with airflow obstruction showed a pattern of cellu...

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Bibliographic Details
Published in:Thorax 2006-02, Vol.61 (2), p.129-133
Main Authors: Malerba, M, Ricciardolo, F, Radaeli, A, Torregiani, C, Ceriani, L, Mori, E, Bontempelli, M, Tantucci, C, Grassi, V
Format: Article
Language:English
Subjects:
AAT
AATD
Age
Aged
airway inflammation
alpha 1-Antitrypsin Deficiency - metabolism
alpha 1-Antitrypsin Deficiency - pathology
alpha 1-Antitrypsin Deficiency - physiopathology
Alpha-1-Antitrypsin Deficiency
alpha-1-trypsin
alpha-1-trypsin deficiency
Asymptomatic
Biological and medical sciences
Bronchitis - metabolism
Bronchitis - pathology
Carbon Monoxide - metabolism
carbon monoxide transfer factor
Case-Control Studies
Chronic obstructive pulmonary disease
COPD
Female
FEV1
Forced Expiratory Volume - physiology
forced expiratory volume in 1 second
forced vital capacity
FVC
Humans
induced sputum
Inflammation
interleukin
Interleukin-8 - metabolism
Leukotriene B4 - metabolism
Male
Medical sciences
Middle Aged
Neutrophils
Neutrophils - pathology
Pneumology
Sputum - cytology
Statistical analysis
Steroids
Tlco
Variance analysis
Vital Capacity - physiology
Womens health
α1-antitrypsin deficiency
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Summary:Background: Severe alpha-1-antitrypsin deficiency (AATD), due to homozygosity for the protease inhibitor (Pi) Z allele, is a genetic risk factor for chronic obstructive pulmonary disease (COPD). In a previous study the sputum of severe AATD subjects with airflow obstruction showed a pattern of cellular inflammation similar to COPD patients. It is uncertain whether heterozygotes for the Z allele or intermediate deficiency (PiMZ) have an increased risk of developing COPD. Methods: Sputum cell counts and the supernatant level of the neutrophil chemoattractant interleukin (IL)-8 were investigated by sputum induction in 10 non-smoker asymptomatic PiMZ subjects with normal pulmonary function, 10 patients with stable COPD, and 10 age matched normal subjects. Data are expressed as mean (SD). Results: The mean (SD) number of neutrophils was significantly higher (p
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.2005.043471