Inverse Enzymatic Changes in Neurons and Glia during Increased Function and Hypoxia

Following stimulation of the vestibular nerve in the rabbit, respiratory enzyme activities increased in Deiters' nerve cells. The anaerobic glycolysis, measured as 10-4 μl CO2 per hour per cell, was found to decrease concomitantly by 25 to 40 per cent, suggesting a Pasteur effect. By contrast,...

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Bibliographic Details
Published in:The Journal of cell biology 1963-03, Vol.16 (3), p.521-525
Main Authors: Hamberger, Anders, Hydén, Holger
Format: Article
Language:English
Subjects:
Animals
Carbohydrate Metabolism
Cells
Cytochromes
Enzyme activity
Glycolysis
Hypoxia
Neuroglia
Neurons
Old Medline
Oxidases
Oxygen Consumption
Oxygen partial pressure
Rabbits
RNA
Vestibular Nerve
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Summary:Following stimulation of the vestibular nerve in the rabbit, respiratory enzyme activities increased in Deiters' nerve cells. The anaerobic glycolysis, measured as 10-4 μl CO2 per hour per cell, was found to decrease concomitantly by 25 to 40 per cent, suggesting a Pasteur effect. By contrast, in the surrounding glia the anaerobic glycolysis increased and the respiratory enzyme activity decreased, suggesting a Crabtree effect. The evidence is discussed for a regulatory metabolic mechanism operating between the neuron and its glia. Hypoxia of 8 per cent O2 caused an increase of both oxygen consumption and CO2 production in the nerve cells, but did not change the glia values.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.16.3.521