Taxol Induces Postmitotic Myoblasts to Assemble Interdigitating Microtubule-Myosin Arrays That Exclude Actin Filaments

Taxol has the following effects on myogenic cultures: (a) it blocks cell replication of presumptive myoblasts and fibroblasts. (b) It induces the aggregation of microtubules into sheets or massive cables in presumptive myoblasts and fibroblasts, but not in postmitotic, mononucleated myoblasts. (c) I...

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Published in:The Journal of cell biology 1981-08, Vol.90 (2), p.300-308
Main Authors: Antin, Parker B., Forry-Schaudies, Suzanne, Friedman, Thea M., Tapscott, S. J., Holtzer, Howard
Format: Article
Language:English
Subjects:
Alkaloids - pharmacology
Animals
Cell Cycle - drug effects
Cells
Cells, Cultured
Chick Embryo
Cultured cells
Cytoskeleton - drug effects
Cytoskeleton - ultrastructure
Epithelial cells
Fibroblasts
Fibroblasts - drug effects
Microfilaments
Microtubules
Microtubules - drug effects
Microtubules - ultrastructure
Muscle fibers
Muscles - cytology
Muscles - drug effects
Myoblasts
Myofibrils
Myosins
Neurons
Paclitaxel
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container_end_page 308
container_issue 2
container_start_page 300
container_title The Journal of cell biology
container_volume 90
creator Antin, Parker B.
Forry-Schaudies, Suzanne
Friedman, Thea M.
Tapscott, S. J.
Holtzer, Howard
description Taxol has the following effects on myogenic cultures: (a) it blocks cell replication of presumptive myoblasts and fibroblasts. (b) It induces the aggregation of microtubules into sheets or massive cables in presumptive myoblasts and fibroblasts, but not in postmitotic, mononucleated myoblasts. (c) It induces normally elongated postmitotic myoblasts to form stubby, star-shaped cells. (d) It reversibly blocks the fusion of the star-shaped myoblasts into multinucleated myotubes. (e) It augments the number of microtubules in postmitotic myoblasts, and these are assembled into interdigitating arrays of microtubules and myosin filaments. (f) Actin filaments are largely excluded from these interdigitating microtubule-myosin complexes. (g) The myosin filaments in the interdigitating microtubule-myosin arrays are aligned laterally, forming A-bands ∼1.5 μm long.
doi_str_mv 10.1083/jcb.90.2.300
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source JSTOR Archival Journals and Primary Sources Collection
subjects Alkaloids - pharmacology
Animals
Cell Cycle - drug effects
Cells
Cells, Cultured
Chick Embryo
Cultured cells
Cytoskeleton - drug effects
Cytoskeleton - ultrastructure
Epithelial cells
Fibroblasts
Fibroblasts - drug effects
Microfilaments
Microtubules
Microtubules - drug effects
Microtubules - ultrastructure
Muscle fibers
Muscles - cytology
Muscles - drug effects
Myoblasts
Myofibrils
Myosins
Neurons
Paclitaxel
title Taxol Induces Postmitotic Myoblasts to Assemble Interdigitating Microtubule-Myosin Arrays That Exclude Actin Filaments
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