Regulation of Agrin-Induced Acetylcholine Receptor Aggregation by Ca++ and Phorbol Ester

Agrin, a protein extracted from the electric organ of Torpedo californica, induces the formation of specializations on cultured chick myotubes that resemble the postsynaptic apparatus at the neuromuscular junction. The aim of the studies reported here was to characterize the effects of agrin on the...

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Bibliographic Details
Published in:The Journal of cell biology 1988-07, Vol.107 (1), p.267-278
Main Author: Wallace, Bruce G.
Format: Article
Language:English
Subjects:
Aggregation
Agrin
Animals
Biological and medical sciences
Calcium - pharmacology
Cell aggregates
Cell structures and functions
Chick Embryo
Cholinergic receptors
Cholinesterases - metabolism
Cobalt - pharmacology
Cultured cells
Dose-Response Relationship, Drug
Energy Metabolism
Fundamental and applied biological sciences. Psychology
Magnesium - pharmacology
Manganese - pharmacology
Microscopy, Fluorescence
Molecular and cellular biology
Molecules
Muscle fibers
Nerve Tissue Proteins - pharmacology
Neurons
Pain
Receptor Aggregation - drug effects
Receptors
Receptors, Cholinergic - drug effects
Strontium - pharmacology
Synapses
Tetradecanoylphorbol Acetate - pharmacology
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Summary:Agrin, a protein extracted from the electric organ of Torpedo californica, induces the formation of specializations on cultured chick myotubes that resemble the postsynaptic apparatus at the neuromuscular junction. The aim of the studies reported here was to characterize the effects of agrin on the distribution of acetylcholine receptors (AChRs) and cholinesterase as a step toward determining agrin's mechanism of action. When agrin was added to the medium bathing chick myotubes small (
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.107.1.267