Neutrophil-derived leukotriene B4 is required for inflammatory arthritis

Neutrophils serve as a vanguard of the acute innate immune response to invading pathogens. Neutrophils are also abundant at sites of autoimmune inflammation, such as the rheumatoid joint, although their pathophysiologic role is incompletely defined and relevant effector functions remain obscure. Usi...

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Bibliographic Details
Published in:The Journal of experimental medicine 2006-04, Vol.203 (4), p.837-842
Main Authors: Chen, Mei, Lam, Bing K, Kanaoka, Yoshihide, Nigrovic, Peter A, Audoly, Laurent P, Austen, K Frank, Lee, David M
Format: Article
Language:English
Subjects:
Animals
Arthritis - genetics
Arthritis - immunology
Arthritis - metabolism
Arthritis - pathology
Brief Definitive Reports
Cells, Cultured
Genetic Predisposition to Disease
Inflammation - genetics
Inflammation - immunology
Inflammation - metabolism
Inflammation - pathology
Leukotriene B4 - biosynthesis
Leukotriene B4 - deficiency
Leukotriene B4 - genetics
Leukotriene B4 - physiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Neutrophils - immunology
Neutrophils - metabolism
Neutrophils - pathology
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Summary:Neutrophils serve as a vanguard of the acute innate immune response to invading pathogens. Neutrophils are also abundant at sites of autoimmune inflammation, such as the rheumatoid joint, although their pathophysiologic role is incompletely defined and relevant effector functions remain obscure. Using genetic and pharmacologic approaches in the K/BxN serum transfer model of arthritis, we find that autoantibody-driven erosive synovitis is critically reliant on the generation of leukotrienes, and more specifically on leukotriene B4 (LTB4), for disease induction as well as perpetuation. Pursuing the cellular source for this mediator, we find via reconstitution experiments that mast cells are a dispensable source of leukotrienes, whereas arthritis susceptibility can be restored to leukotriene-deficient mice by intravenous administration of wild-type neutrophils. These experiments demonstrate a nonredundant role for LTB4 in inflammatory arthritis and define a neutrophil mediator involved in orchestrating the synovial eruption.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.20052371