Binding to and antibacterial effect of ampicillin, neomycin and polymyxin B on human faeces

Neomycin and polymyxin B, used during selective decontamination of the gastrointestinal tract, were studied for their effect on the human faecal flora in vitro. The selective effect was found to be associated with a relative insusceptibility of the obligate anaerobic flora as compared with the facul...

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Bibliographic Details
Published in:The Journal of hygiene 1984-08, Vol.93 (1), p.27-34
Main Authors: Hazenberg, M. P., Pennock-Schröder, A. M., Van Den Boom, M., Van De Merwe, J. P.
Format: Article
Language:English
Subjects:
Ampicillin - metabolism
Ampicillin - pharmacology
Anaerobic bacteria
Antibiotics
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antimicrobials
Applied microbiology
Bacteria - drug effects
Bacteria, Anaerobic - drug effects
Biological and medical sciences
Decontamination
Escherichia coli
Escherichia coli - drug effects
Fecal flora
Feces - metabolism
Feces - microbiology
Flora
Fundamental and applied biological sciences. Psychology
Humans
Infections
Intestinal microorganisms
Microbiology
Neomycin - metabolism
Neomycin - pharmacology
Polymyxin B - metabolism
Polymyxin B - pharmacology
Polymyxins
Polymyxins - pharmacology
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Summary:Neomycin and polymyxin B, used during selective decontamination of the gastrointestinal tract, were studied for their effect on the human faecal flora in vitro. The selective effect was found to be associated with a relative insusceptibility of the obligate anaerobic flora as compared with the facultatively anaerobic Gram-negative rods (Escherichia coli). Both neomycin and polymyxin B were bound by human faeces, in contrast to ampicillin. The results may explain the selective effect of neomycin and polymyxin B on the human flora in vivo.
ISSN:0022-1724
2396-8184
DOI:10.1017/S0022172400060897