The influence of technique on the sensitivity of monkeys to intraspinally inoculated poliovirus

1. Two methods of injecting monkeys intraspinally are compared. 2. It has been shown that the technique of inserting the needle through the cord and withdrawing it 1–2 mm. before injection (Sabin's technique) gives a less widespread distribution of inoculum than the alternative method of making...

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Bibliographic Details
Published in:Epidemiology and infection 1961-12, Vol.59 (4), p.395-399
Main Authors: Beswick, T. S. L., Coid, C. R.
Format: Article
Language:English
Subjects:
Animals
Enterovirus C, Human
Haplorhini
Humans
Injections
Inks
Inoculation
Inoculum
Lesions
Medical syringes
Old Medline
Paralysis
Poliomyelitis
Poliovirus
Viruses
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Summary:1. Two methods of injecting monkeys intraspinally are compared. 2. It has been shown that the technique of inserting the needle through the cord and withdrawing it 1–2 mm. before injection (Sabin's technique) gives a less widespread distribution of inoculum than the alternative method of making the injection as soon as the tip of the needle is within the substance of the spinal cord (‘standard technique’). 3. When attenuated Type 3 poliovirus is injected into cynomolgus monkeys by Sabin's technique, the incidence of paralysis and poliomyelitis lesions observed is less than when it is injected by the ‘standard technique’. 4. The relative merits of the two techniques are discussed.
ISSN:0950-2688
0022-1724
1469-4409
DOI:10.1017/S0022172400039085