What brings pericytes to tumor vessels?

Paracrine signaling via platelet-derived growth factor B (PDGFB), expressed by endothelial cells, and its receptor PDGFR-beta, expressed by pericytes, plays a central role in blood vessel maturation. A new study (see the related article beginning on page 1142) reveals that it is not just the presenc...

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Bibliographic Details
Published in:The Journal of clinical investigation 2003-10, Vol.112 (8), p.1134-1136
Main Authors: Jain, Rakesh K, Booth, Michael F
Format: Article
Language:English
Subjects:
Animals
Biomedical research
Cell Movement
Endothelium, Vascular - cytology
Endothelium, Vascular - physiology
Mice
Neoplasms, Experimental - blood supply
Neovascularization, Pathologic - etiology
Pericytes - physiology
Proto-Oncogene Proteins c-sis - physiology
Receptor, Platelet-Derived Growth Factor beta - physiology
Vascular Endothelial Growth Factor A - physiology
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Summary:Paracrine signaling via platelet-derived growth factor B (PDGFB), expressed by endothelial cells, and its receptor PDGFR-beta, expressed by pericytes, plays a central role in blood vessel maturation. A new study (see the related article beginning on page 1142) reveals that it is not just the presence of PDGFB, but how it is presented to pericytes, that determines the quality of the endothelium-pericyte interaction.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI200320087