On the entropy of protein folding

The failure to appreciate that the hydration of polar groups is a major contribution to the entropy of protein unfolding has led to considerable underestimates for the loss of configurational freedom when a protein chain folds.

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Bibliographic Details
Published in:Protein science 1996-03, Vol.5 (3), p.507-510
Main Authors: Makhatadze, George I., Privalov, Peter L.
Format: Article
Language:English
Subjects:
Calorimetry
configurational entropy
hydration
Molecular Conformation
Protein Folding
Proteins - chemistry
Ribonucleases - chemistry
Ribonucleases - metabolism
stability
Temperature
Thermodynamics
Ubiquitins - chemistry
Ubiquitins - metabolism
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Description
Summary:The failure to appreciate that the hydration of polar groups is a major contribution to the entropy of protein unfolding has led to considerable underestimates for the loss of configurational freedom when a protein chain folds.
ISSN:0961-8368
1469-896X
DOI:10.1002/pro.5560050312