Pervasive and Largely Lineage-Specific Adaptive Protein Evolution in the Dosage Compensation Complex of Drosophila melanogaster

Dosage compensation refers to the equalization of X-linked gene transcription among heterogametic and homogametic sexes. In Drosophila, the dosage compensation complex (DCC) mediates the twofold hypertranscription of the single male X chromosome. Loss-of-function mutations at any DCC protein-coding...

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Bibliographic Details
Published in:Genetics (Austin) 2007-11, Vol.177 (3), p.1959-1962
Main Authors: Levine, M.T, Holloway, A.K, Arshad, U, Begun, D.J
Format: Article
Language:English
Subjects:
Adaptation, Physiological
amino acid sequences
Amino acids
Animals
dosage compensation complex
Dosage Compensation, Genetic
Drosophila - genetics
Drosophila - physiology
Drosophila melanogaster
Drosophila melanogaster - genetics
Drosophila melanogaster - physiology
Drosophila Proteins - genetics
Drosophila Proteins - physiology
Evolution
Evolution, Molecular
Female
fruit flies
gene dosage
insect proteins
lethal genes
Male
males
molecular sequence data
Mutation
natural selection
Polymorphism, Genetic
Population genetics
Proteins
Selection, Genetic
sex linkage
Species Specificity
transcription (genetics)
X chromosome
X Chromosome - genetics
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Summary:Dosage compensation refers to the equalization of X-linked gene transcription among heterogametic and homogametic sexes. In Drosophila, the dosage compensation complex (DCC) mediates the twofold hypertranscription of the single male X chromosome. Loss-of-function mutations at any DCC protein-coding gene are male lethal. Here we report a population genetic analysis suggesting that four of the five core DCC proteins--MSL1, MSL2, MSL3, and MOF--are evolving under positive selection in D. melanogaster. Within these four proteins, several domains that range in function from X chromosome localization to protein-protein interactions have elevated, D. melanogaster-specific, amino acid divergence.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1534/genetics.107.079459