Definitive evidence for hypoxic cells influencing cure in cancer therapy

From an analysis of 2803 patients with carcinoma of the cervix treated by radiation therapy, a 62% cure rate can be shown. In those patients with Stage IIb and III disease, a haemoglobin level during treatment of below 12 g% was associated with a significantly higher pelvic recurrence rate, and also...

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Bibliographic Details
Published in:British journal of cancer. Supplement 1978-06, Vol.3, p.302-306
Main Authors: Bush, R S, Jenkin, R D, Allt, W E, Beale, F A, Bean, H, Dembo, A J, Pringle, J F
Format: Article
Language:English
Subjects:
Female
Hemoglobinometry
Humans
Neoplasm Recurrence, Local
Neoplasm Staging
Oxygen
Prognosis
Uterine Cervical Neoplasms - blood
Uterine Cervical Neoplasms - mortality
Uterine Cervical Neoplasms - radiotherapy
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Summary:From an analysis of 2803 patients with carcinoma of the cervix treated by radiation therapy, a 62% cure rate can be shown. In those patients with Stage IIb and III disease, a haemoglobin level during treatment of below 12 g% was associated with a significantly higher pelvic recurrence rate, and also lower cure rate, than for those with a haemoglobin level 12g% or more. A prospective study shows that the correction of anaemia is associated with a decreased pelvic recurrence rate and an increased cure rate consistent with tumour hypoxia being greater in anaemic patients than in those with a normal haemoglobin level. It is also consistent with the thesis that hypoxia controls the radiation local control rate in patients with advanced carcinoma of the cervix.
ISSN:0306-9443